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Entry version 95 (07 Apr 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Sol narae, isoform C

Gene

sona

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, ProteaseARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1650814, Collagen biosynthesis and modifying enzymes
R-DME-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.A51

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sol narae, isoform CImported (EC:3.4.24.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sonaImported
Synonyms:CG11169Imported, DimpImported, dimpImported, Dmel\CG9850Imported
ORF Names:CG9850Imported, Dmel_CG9850Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034903, sona

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500286631920 – 1102Sequence analysisAdd BLAST1083

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B7YZP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034903, Expressed in adult organism and 28 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B7YZP6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B7YZP6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0288559

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini313 – 545Peptidase M12BInterPro annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 79DisorderedSequence analysisAdd BLAST22
Regioni265 – 305DisorderedSequence analysisAdd BLAST41
Regioni646 – 729DisorderedSequence analysisAdd BLAST84
Regioni754 – 784DisorderedSequence analysisAdd BLAST31
Regioni841 – 945DisorderedSequence analysisAdd BLAST105
Regioni964 – 1005DisorderedSequence analysisAdd BLAST42
Regioni1017 – 1102DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi651 – 676AcidicSequence analysisAdd BLAST26
Compositional biasi686 – 724PolarSequence analysisAdd BLAST39
Compositional biasi841 – 899PolarSequence analysisAdd BLAST59
Compositional biasi909 – 945PolarSequence analysisAdd BLAST37
Compositional biasi1021 – 1079PolarSequence analysisAdd BLAST59

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7YZP6

Database of Orthologous Groups

More...
OrthoDBi
192004at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B7YZP6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04272, ZnMc_salivary_gland_MPs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR034030, ZnMc_salivary_gland_MPs

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B7YZP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPLVLFTA LLLVSSTICQ GLPDLHKQMT PEQLQSVFHV DTHDAVPHYE
60 70 80 90 100
LVQLQHHENN HNRRRRSIGK GPKVNAALPP HHVKKDLSKN AYYSELKHEA
110 120 130 140 150
LASGGNHLFA PEVSAIKSHN VSFSAFGQHL NLSLRATQGL FKGAPHQLRM
160 170 180 190 200
WTVGSEPNAT HGLDLQEIVH EQHTSNDVGE VFQDEKNMAA ILMRRHMETG
210 220 230 240 250
DLIMEGSIGH DLVIKPLPHE LSPNPEESHH IIYKREASAA EGQLSDFAFM
260 270 280 290 300
EPDDLLASEK LERLQRRQRR SRRSAPSSPD FEDLNDEDEG ALDGEPQVAE
310 320 330 340 350
SRTRSRRQAP YIIYPEVLVI VDYDGYRLHG GDNLQVKRYF ISFWNGVDLR
360 370 380 390 400
YRLLKGPRIR ISIAGIIISR GRDATPYLER NRVGRDAIDS AAALTDMGKY
410 420 430 440 450
LFRERRLPVY DIAVAITKLD MCRRTSAYGE CNRGTAGFAY VGGACVVNKR
460 470 480 490 500
LEKVNSVAII EDTGGFSGII VAAHEVGHLL GAVHDGSPPP SYLGGPGAQR
510 520 530 540 550
CRWEDGYIMS DLRHTERGFR WSACTVQSFH HFLNGDTATC LHNAPHEDSA
560 570 580 590 600
LGRSLPGTLL SLDAQCRRDR GTYACFKDER VCAQLFCFDA QTGYCVAYRP
610 620 630 640 650
AAEGSACGNG YHCLDGRCTP LPSNIIPDYG HNYRLVYNKI DNKKDAAEDV
660 670 680 690 700
ESSSEETESQ EDETESVEDQ DEGTTSSEEQ EDNKIEQSSA AGGAAAQSTT
710 720 730 740 750
TARSTTTTTV RTTSTTTTTA KPKSKSFGYL HRSLPERQWM QDNGVLVTTR
760 770 780 790 800
ISSSVSSSSS GSSSGEAAAT STRRPTTTTT TQTPNLFQIY THELRKQIEY
810 820 830 840 850
YLHMLQTQQH ATKFQPEQQQ QQSQQQQSIV EIPLVQKSLT NYSVTSSSSS
860 870 880 890 900
TSNGAKQQPP SNKDENQRQQ QQQQQAQQQL QDGLPDEENE ATAGIQSNEA
910 920 930 940 950
IERQKRKFPT TPTAATSAAQ KSATPATPAT SATSARPTPT TAKPITTSSF
960 970 980 990 1000
LDAYFKKLQA LHDAGSASSS TTTTTTTSVS SSVSSATSSK QQHPQQQQQQ
1010 1020 1030 1040 1050
QVQQIADGSH FLKRTPHRSS LKAYKTSSSS SNNSSSQTQQ QQQQQQQQYA
1060 1070 1080 1090 1100
TNYIGDTTNN QPAVLDNSGS ASSTTETAKK PKIKTQKLIR RTRVMQTQTQ

TI
Length:1,102
Mass (Da):121,629
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22425616C00A10C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2MGN5Q2MGN5_DROME
Sol narae, isoform E
sona CG11169, Dimp, dimp, Dmel\CG9850, CG9850
896Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFG8A0A0B4KFG8_DROME
Sol narae, isoform D
sona CG11169, Dimp, dimp, Dmel\CG9850, CG9850
913Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W1J9Q9W1J9_DROME
LP23513p
sona CG11169, CG9850-RA, Dimp, dimp, Dmel\CG9850
639Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGD6A0A0B4KGD6_DROME
Sol narae, isoform F
sona CG11169, Dimp, dimp, Dmel\CG9850, CG9850
638Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: ACL83199.1

NCBI Reference Sequences

More...
RefSeqi
NP_001137746.1, NM_001144274.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0290120; FBpp0288559; FBgn0034903

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: ACL83199.1
RefSeqiNP_001137746.1, NM_001144274.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0288559

Protein family/group databases

MEROPSiM12.A51

Proteomic databases

PaxDbiB7YZP6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
37762

Genome annotation databases

EnsemblMetazoaiFBtr0290120; FBpp0288559; FBgn0034903
GeneIDi37762

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37762
FlyBaseiFBgn0034903, sona

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
InParanoidiB7YZP6
OrthoDBi192004at2759
PhylomeDBiB7YZP6

Enzyme and pathway databases

ReactomeiR-DME-1650814, Collagen biosynthesis and modifying enzymes
R-DME-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37762, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37762

Gene expression databases

BgeeiFBgn0034903, Expressed in adult organism and 28 other tissues
ExpressionAtlasiB7YZP6, baseline and differential
GenevisibleiB7YZP6, DM

Family and domain databases

CDDicd04272, ZnMc_salivary_gland_MPs, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR034030, ZnMc_salivary_gland_MPs
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7YZP6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7YZP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 7, 2021
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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