B1YB28 · COXX_PYRNV
- ProteinProtoheme IX farnesyltransferase
- GenectaB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids278 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous
Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Catalytic activity
- heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
Pathway
Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protoheme IX farnesyltransferase activity | |
Biological Process | heme O biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtoheme IX farnesyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum
Accessions
- Primary accessionB1YB28
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | ||||
Sequence: VIWLLILSSVVGYVYAAGTVD | ||||||
Transmembrane | 36-56 | Helical | ||||
Sequence: LAALTAAATLAVGGSAAFNHY | ||||||
Transmembrane | 72-92 | Helical | ||||
Sequence: PLPAGAIPPSNALVYSLALSA | ||||||
Transmembrane | 105-124 | Helical | ||||
Sequence: LPGVFVALGWFFYAVVYTVW | ||||||
Transmembrane | 130-150 | Helical | ||||
Sequence: WLNILGGGFAGNATFLGGYAL | ||||||
Transmembrane | 157-177 | Helical | ||||
Sequence: LPAVLISFAIYLWIPSHIWAL | ||||||
Transmembrane | 204-224 | Helical | ||||
Sequence: AIISALNIASAAYILWLYLVF | ||||||
Transmembrane | 228-248 | Helical | ||||
Sequence: LPGLALVLAGVAGTVATSALA | ||||||
Transmembrane | 257-277 | Helical | ||||
Sequence: MWRMYKASSPILTLFLLALVF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000346097 | 1-278 | Protoheme IX farnesyltransferase | |||
Sequence: MNPYIVLLKPRVIWLLILSSVVGYVYAAGTVDWGRLAALTAAATLAVGGSAAFNHYWERDIDAAMARTARRPLPAGAIPPSNALVYSLALSATGILLGFYLLGPLPGVFVALGWFFYAVVYTVWLKRRTWLNILGGGFAGNATFLGGYALGKGTVDLPAVLISFAIYLWIPSHIWALAYKYREDYRRAGVPMLPAIIDEGKAVAIISALNIASAAYILWLYLVFGRGLPGLALVLAGVAGTVATSALALREKSDRAMWRMYKASSPILTLFLLALVFS |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length278
- Mass (Da)29,931
- Last updated2008-05-20 v1
- Checksum312E5A415144DBBC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001014 EMBL· GenBank· DDBJ | ACB40728.1 EMBL· GenBank· DDBJ | Genomic DNA |