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Entry version 85 (07 Apr 2021)
Sequence version 1 (02 Oct 2007)
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Protein
Submitted name:

TMEM63A protein

Gene

TMEM63A

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelARBA annotation
Biological processIon transport, Transport
LigandCalciumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TMEM63A proteinImported
Submitted name:
Transmembrane protein 63AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM63AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:36103, TMEM63A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 71HelicalSequence analysisAdd BLAST23
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei191 – 210HelicalSequence analysisAdd BLAST20
Transmembranei418 – 441HelicalSequence analysisAdd BLAST24
Transmembranei461 – 484HelicalSequence analysisAdd BLAST24
Transmembranei505 – 528HelicalSequence analysisAdd BLAST24
Transmembranei610 – 640HelicalSequence analysisAdd BLAST31
Transmembranei661 – 683HelicalSequence analysisAdd BLAST23
Transmembranei695 – 719HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A7MB88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000002854, Expressed in heart and 18 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000003701

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 210RSN1_TMInterPro annotationAdd BLAST158
Domaini227 – 409PHM7_cytInterPro annotationAdd BLAST183
Domaini421 – 691RSN1_7TMInterPro annotationAdd BLAST271

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSC1 (TC 1.A.17) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1134, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159576

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015647_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LITWPVL

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR035979, RBD_domain_sf
IPR003864, RSN1_7TM
IPR026957, TMEM63A

The PANTHER Classification System

More...
PANTHERi
PTHR13018:SF24, PTHR13018:SF24, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A7MB88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTESPFLELW QSRAVAIPER LGIGDQPNDS YCYNSAKNST VLQGVTFGGI
60 70 80 90 100
PTVLFIDVTC FLFLIAAFSI IRRKFWDYGR IALVSEGNSE SRFRRLSSSS
110 120 130 140 150
SGQQDFESEM GLCSWLTAIF RLHDDQILEW CGEDAIHYLS FQRHIIFLLV
160 170 180 190 200
VVSCLSLCVI LPVNLSGDLL DKDPYSFGRT TIANLQTDNN LLWLHTVFAI
210 220 230 240 250
LYLILTVVFM RHHTQSIKYK EESLVRRTLF VTGLPRHAKK ETVESHFRDA
260 270 280 290 300
YPTCEVVEVQ LCYDVAKLIY LCKERKKTEK SLTYYTNLQV KTGQRTFINP
310 320 330 340 350
KPCGQFCCCE VRGCEWEDAI SYYTRMKDGL MERITEEECR VQDQPLGMAF
360 370 380 390 400
VTFQEKSMAT YVLKDFNACK CQGLQCKGEP QPSSHGRELR ISRWSVTFAA
410 420 430 440 450
YPEDICWKNL SIQGFRWWFQ WLGINFILFV VLFFLTTPSI ILSTMDKFNV
460 470 480 490 500
TKPIHALNNP VISQFFPTLL LWSFSALLPT IVYYSTLLES HWTKSGENWI
510 520 530 540 550
MMTKVYIFLI FMVLILPSLG LTSLDFFFRW LFDKTSSEAS IRLECVFLPD
560 570 580 590 600
QGAFFVNYVI ASAFIGNGME LLRLPGLILY TFRMVMAKTA ADRKNVKQNQ
610 620 630 640 650
AFEYEFGAMY AWMLCVFTVI MAYSITCPII VPFGLIYILL KHMVDRHNLY
660 670 680 690 700
FAYLPAKLEK RIHFAAVNQA LAAPILCLFW LYFFSFLRLG LKAPLTLFTF
710 720 730 740 750
LVLLLTILVC LAYTCFGCFK HLSPLNYKTE ESASDKGNEA GAHVPPPFTP
760 770 780 790 800
YVPRILNSSS SEKTALSPQQ QTYGAINNIS GTVAGQCLAQ SPEDRVAAAD

QGD
Length:803
Mass (Da):91,765
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA987704CF7B8879
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LXL9A0A3Q1LXL9_BOVIN
Transmembrane protein 63A
TMEM63A
753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LUE3A0A3Q1LUE3_BOVIN
Transmembrane protein 63A
TMEM63A
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC151398 mRNA Translation: AAI51399.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095632.1, NM_001102162.1
XP_005216879.1, XM_005216822.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000003701; ENSBTAP00000003701; ENSBTAG00000002854
ENSBTAT00000076284; ENSBTAP00000071313; ENSBTAG00000002854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
534017

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:534017

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151398 mRNA Translation: AAI51399.1
RefSeqiNP_001095632.1, NM_001102162.1
XP_005216879.1, XM_005216822.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003701

Proteomic databases

PRIDEiA7MB88

Genome annotation databases

EnsembliENSBTAT00000003701; ENSBTAP00000003701; ENSBTAG00000002854
ENSBTAT00000076284; ENSBTAP00000071313; ENSBTAG00000002854
GeneIDi534017
KEGGibta:534017

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9725
VGNCiVGNC:36103, TMEM63A

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
GeneTreeiENSGT00940000159576
HOGENOMiCLU_015647_2_0_1
OMAiLITWPVL
OrthoDBi395194at2759
TreeFamiTF324300

Gene expression databases

BgeeiENSBTAG00000002854, Expressed in heart and 18 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR035979, RBD_domain_sf
IPR003864, RSN1_7TM
IPR026957, TMEM63A
PANTHERiPTHR13018:SF24, PTHR13018:SF24, 1 hit
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7MB88_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7MB88
Secondary accession number(s): F1MG11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 7, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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