A6W0Z9 · HLDE_MARMS

Function

function

Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site196-199ATP (UniProtKB | ChEBI)
Active site265

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • Ordered locus names
      Mmwyl1_3475

Organism names

Accessions

  • Primary accession
    A6W0Z9

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003355561-475Bifunctional protein HldE

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-320Ribokinase
Region346-475Cytidylyltransferase

Sequence similarities

In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
In the C-terminal section; belongs to the cytidylyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    475
  • Mass (Da)
    51,698
  • Last updated
    2007-08-21 v1
  • Checksum
    558D88E5E5B370E5
MNSSYLNFKDKHILVVGDVMLDRYWHGGTSRISPEAPVQVVKVSSIEDRPGGAANVALGLAKLGVSVTLVGVVGNDENADVLARCLEDAGVICRFVRSETLPTITKLRVMSRHQQLIRLDFEEREDSLSQNEALAKVVEECLPKSDAVIFSDYAKGCLADVQSLIKLSNAAKVPSFVDPKGNDFSIYQGATLVKPNLLEFETIVGKCSSTKELEEKAKALREQFGWKALLVTRGEDGLILLSDDKPPFSLATAAKEVFDVTGAGDTVVAVLTAVYVTSKRFIDAVEYANQAAGYVVGKLGTASISAERLDAIMFQRSHNTNFGVLSPKDLLEQIKLAQMNGEKIVFTNGCFDILHPGHIAYMKQAKALGDRLIVAVNTDASVKRLKGEKRPINNLIHRMSVLEGVGSIDWVTWFDEDTPKEIIEFLTPDVLVKGGDYTIETIVGADHVLAHGGEVKVLTFVDGYSTTSIIEKANL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000749
EMBL· GenBank· DDBJ
ABR72378.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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