A5WAF7 · COAD_PSEP1

Function

function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site9substrate
Binding site9-10ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Site17Transition state stabilizer
Binding site41substrate
Binding site73substrate
Binding site87substrate
Binding site88-90ATP (UniProtKB | ChEBI)
Binding site98ATP (UniProtKB | ChEBI)
Binding site123-129ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantetheine-phosphate adenylyltransferase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphopantetheine adenylyltransferase
  • EC number
  • Alternative names
    • Dephospho-CoA pyrophosphorylase
    • Pantetheine-phosphate adenylyltransferase
      (PPAT
      )

Gene names

    • Name
      coaD
    • Ordered locus names
      Pput_4997

Organism names

Accessions

  • Primary accession
    A5WAF7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000112101-159Phosphopantetheine adenylyltransferase

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Sequence similarities

Belongs to the bacterial CoaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    17,794
  • Last updated
    2007-07-10 v1
  • Checksum
    547CF849C358C6CF
MNRVLYPGTFDPITKGHGDLVERASRLFDHVIIAVAASPKKNPLFPLEQRVELAREVTKHLPNVEVIGFSSLLAHFAKEQGANVFLRGLRAVSDFEYEFQLANMNRQLAPDVESLFLTPSERYSFISSTLVREIAALGGDISKFVHPVVADALTERFKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000712
EMBL· GenBank· DDBJ
ABQ81117.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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