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A2VEC9 · SSPO_HUMAN

  • Protein
    SCO-spondin
  • Gene
    SSPOP
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Involved in the modulation of neuronal aggregation (By similarity).
May be involved in developmental events during the formation of the central nervous system (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Cellular Componentplasma membrane protein complex
Molecular Functionpeptidase inhibitor activity
Biological Processcell adhesion

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    SCO-spondin
  • Alternative names
    • SCO-spondin pseudogene

Gene names

    • Name
      SSPOP
    • Synonyms
      KIAA2036, SSPO

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A2VEC9
  • Secondary accessions
    • A0A096LNW2
    • Q76B61

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_052660146in dbSNP:rs709061
Natural variantVAR_052661298in dbSNP:rs17754559
Natural variantVAR_059863540in dbSNP:rs855677
Natural variantVAR_0757091002found in patient with Joubert syndrome; uncertain significance; dbSNP:rs199648588
Natural variantVAR_0598641273in dbSNP:rs709060
Natural variantVAR_0526621274in dbSNP:rs709060
Natural variantVAR_0598651425in dbSNP:rs855691
Natural variantVAR_0598661449in dbSNP:rs855692
Natural variantVAR_0598671454in dbSNP:rs2074704
Natural variantVAR_0598681779in dbSNP:rs893601
Natural variantVAR_0598691794in dbSNP:rs1635802
Natural variantVAR_0598701883in dbSNP:rs1076277
Natural variantVAR_0598712018in dbSNP:rs4725314
Natural variantVAR_0619152453in dbSNP:rs2074689
Natural variantVAR_0619162542in dbSNP:rs59522380
Natural variantVAR_0757102799found in patient with Joubert syndrome; uncertain significance; dbSNP:rs181269877
Natural variantVAR_0598722892in dbSNP:rs10260959
Natural variantVAR_0598733274in dbSNP:rs740109
Natural variantVAR_0598743513in dbSNP:rs10952230
Natural variantVAR_0598753894in dbSNP:rs1557955
Natural variantVAR_0598763911in dbSNP:rs745044
Natural variantVAR_0598774030in dbSNP:rs1005603
Natural variantVAR_0619174109in dbSNP:rs12536873
Natural variantVAR_0598784166in dbSNP:rs10233245
Natural variantVAR_0598794332in dbSNP:rs1008336
Natural variantVAR_0598804790in dbSNP:rs1004200
Natural variantVAR_0598814944in dbSNP:rs12534509

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_500022375718-5150SCO-spondin
Glycosylation88N-linked (GlcNAc...) asparagine
Glycosylation130N-linked (GlcNAc...) asparagine
Disulfide bond195↔323
Disulfide bond217↔361
Disulfide bond239↔245
Glycosylation261N-linked (GlcNAc...) asparagine
Glycosylation515N-linked (GlcNAc...) asparagine
Disulfide bond565↔698
Disulfide bond589↔735
Glycosylation820N-linked (GlcNAc...) asparagine
Glycosylation912N-linked (GlcNAc...) asparagine
Glycosylation945N-linked (GlcNAc...) asparagine
Glycosylation987N-linked (GlcNAc...) asparagine
Disulfide bond1015↔1147
Disulfide bond1037↔1182
Disulfide bond1058↔1065
Glycosylation1353N-linked (GlcNAc...) asparagine
Disulfide bond1377↔1390
Disulfide bond1384↔1403
Disulfide bond1397↔1412
Disulfide bond1417↔1429
Disulfide bond1424↔1442
Disulfide bond1436↔1453
Disulfide bond1453↔1465
Disulfide bond1460↔1478
Disulfide bond1472↔1487
Disulfide bond1493↔1505
Disulfide bond1500↔1518
Disulfide bond1512↔1529
Disulfide bond1566↔1578
Disulfide bond1573↔1591
Disulfide bond1585↔1600
Disulfide bond1604↔1617
Disulfide bond1611↔1630
Disulfide bond1624↔1641
Glycosylation1651N-linked (GlcNAc...) asparagine
Disulfide bond1657↔1667
Disulfide bond1662↔1680
Glycosylation1664N-linked (GlcNAc...) asparagine
Disulfide bond1674↔1695
Disulfide bond1707↔1743
Disulfide bond1711↔1748
Disulfide bond1722↔1733
Disulfide bond1763↔1803
Disulfide bond1767↔1808
Disulfide bond1777↔1787
Glycosylation1810N-linked (GlcNAc...) asparagine
Disulfide bond1911↔1950
Disulfide bond1922↔1926
Disulfide bond1960↔1965
Glycosylation1994N-linked (GlcNAc...) asparagine
Glycosylation2031N-linked (GlcNAc...) asparagine
Disulfide bond2066↔2225
Glycosylation2134N-linked (GlcNAc...) asparagine
Disulfide bond2235↔2247
Disulfide bond2242↔2260
Disulfide bond2254↔2269
Disulfide bond2392↔2404
Disulfide bond2399↔2417
Disulfide bond2411↔2426
Disulfide bond2465↔2477
Disulfide bond2472↔2490
Disulfide bond2484↔2499
Disulfide bond2502↔2538
Disulfide bond2513↔2517
Disulfide bond2548↔2553
Disulfide bond2568↔2605
Disulfide bond2572↔2610
Disulfide bond2583↔2595
Glycosylation2646N-linked (GlcNAc...) asparagine
Glycosylation2695N-linked (GlcNAc...) asparagine
Disulfide bond2717↔2755
Disulfide bond2728↔2732
Disulfide bond2765↔2769
Disulfide bond2785↔2823
Disulfide bond2789↔2828
Disulfide bond2805↔2813
Disulfide bond2843↔2878
Disulfide bond2847↔2883
Disulfide bond2858↔2868
Glycosylation2937N-linked (GlcNAc...) asparagine
Glycosylation2968N-linked (GlcNAc...) asparagine
Disulfide bond2987↔3025
Disulfide bond2998↔3002
Disulfide bond3035↔3040
Glycosylation3063N-linked (GlcNAc...) asparagine
Glycosylation3117N-linked (GlcNAc...) asparagine
Glycosylation3164N-linked (GlcNAc...) asparagine
Glycosylation3174N-linked (GlcNAc...) asparagine
Disulfide bond3196↔3245
Disulfide bond3200↔3250
Disulfide bond3211↔3235
Disulfide bond3265↔3302
Disulfide bond3269↔3307
Disulfide bond3280↔3292
Glycosylation3311N-linked (GlcNAc...) asparagine
Glycosylation3400N-linked (GlcNAc...) asparagine
Disulfide bond3421↔3464
Disulfide bond3425↔3470
Disulfide bond3436↔3448
Disulfide bond3485↔3520
Disulfide bond3488↔3527
Disulfide bond3498↔3510
Glycosylation3513N-linked (GlcNAc...) asparagine
Glycosylation3523N-linked (GlcNAc...) asparagine
Glycosylation3600N-linked (GlcNAc...) asparagine
Glycosylation3627N-linked (GlcNAc...) asparagine
Disulfide bond3658↔3688
Disulfide bond3662↔3693
Disulfide bond3673↔3678
Glycosylation3793N-linked (GlcNAc...) asparagine
Disulfide bond3824↔3862
Disulfide bond3828↔3867
Disulfide bond3840↔3852
Glycosylation3916N-linked (GlcNAc...) asparagine
Glycosylation3948N-linked (GlcNAc...) asparagine
Disulfide bond3949↔3985
Disulfide bond3960↔3964
Disulfide bond3998↔4003
Disulfide bond4018↔4055
Disulfide bond4022↔4060
Disulfide bond4033↔4045
Glycosylation4141N-linked (GlcNAc...) asparagine
Disulfide bond4162↔4198
Disulfide bond4173↔4177
Disulfide bond4208↔4213
Glycosylation4348N-linked (GlcNAc...) asparagine
Disulfide bond4368↔4405
Disulfide bond4379↔4381
Disulfide bond4415↔4420
Glycosylation4419N-linked (GlcNAc...) asparagine
Glycosylation4734N-linked (GlcNAc...) asparagine
Glycosylation4751N-linked (GlcNAc...) asparagine
Glycosylation4756N-linked (GlcNAc...) asparagine
Disulfide bond4778↔4813
Disulfide bond4782↔4818
Disulfide bond4793↔4802
Glycosylation4866N-linked (GlcNAc...) asparagine
Glycosylation4906N-linked (GlcNAc...) asparagine
Glycosylation4951N-linked (GlcNAc...) asparagine
Glycosylation4958N-linked (GlcNAc...) asparagine
Disulfide bond5044↔5104
Glycosylation5064N-linked (GlcNAc...) asparagine
Disulfide bond5070↔5121
Disulfide bond5080↔5137
Disulfide bond5084↔5139

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain18-102EMI
Domain193-362VWFD 1
Domain470-525TIL 1
Domain563-736VWFD 2
Domain828-881TIL 2
Domain881-940VWFC 1
Domain924-975TIL 3
Domain1013-1183VWFD 3
Domain1276-1332TIL 4
Domain1376-1413LDL-receptor class A 1
Domain1416-1451LDL-receptor class A 2
Domain1452-1488LDL-receptor class A 3
Domain1492-1530LDL-receptor class A 4
Region1529-1561Disordered
Compositional bias1530-1544Pro residues
Compositional bias1545-1559Polar residues
Domain1565-1601LDL-receptor class A 5
Domain1603-1642LDL-receptor class A 6
Domain1656-1694LDL-receptor class A 7
Domain1695-1749TSP type-1 1
Domain1751-1809TSP type-1 2
Domain1825-1864EGF-like 1
Domain1865-1902EGF-like 2
Domain1910-1966TSP type-1 3
Domain1966-2026VWFC 2
Domain2066-2225F5/8 type C
Domain2234-2270LDL-receptor class A 8
Region2306-2338Disordered
Compositional bias2312-2326Polar residues
Domain2391-2427LDL-receptor class A 9
Domain2464-2500LDL-receptor class A 10
Domain2501-2554TSP type-1 4
Domain2556-2611TSP type-1 5
Domain2633-2676TIL 5
Domain2716-2770TSP type-1 6
Domain2773-2829TSP type-1 7
Domain2831-2884TSP type-1 8
Domain2986-3041TSP type-1 9
Domain3042-3084TSP type-1 10
Domain3091-3143TIL 6
Domain3184-3251TSP type-1 11
Domain3253-3308TSP type-1 12
Domain3316-3366TIL 7
Domain3409-3471TSP type-1 13
Domain3473-3528TSP type-1 14
Region3499-3520Disordered
Domain3530-3586TIL 8
Domain3646-3694TSP type-1 15
Domain3812-3868TSP type-1 16
Domain3882-3934TSP type-1 17
Domain3948-4004TSP type-1 18
Domain4006-4061TSP type-1 19
Domain4064-4119TIL 9
Domain4161-4214TSP type-1 20
Domain4255-4307TSP type-1 21
Domain4309-4365TSP type-1 22
Domain4367-4421TSP type-1 23
Domain4425-4480TIL 10
Domain4617-4667TSP type-1 24
Domain4678-4726TIL 11
Domain4766-4819TSP type-1 25
Domain4821-4875TIL 12
Domain4987-5045VWFC 3
Domain5044-5143CTCK

Sequence similarities

Belongs to the thrombospondin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

A2VEC9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    5,150
  • Mass (Da)
    547,841
  • Last updated
    2018-03-28 v2
  • MD5 Checksum
    61E4F2E3BF87B2FD67D4C7DA78194BCE

A2VEC9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1123: Missing
    • 1124-1127: LWDG → MLPP
    • 1640-1640: A → ACVEAPAPPAMRGPPGQAGGPTSSRAPSPPSPPEAQGEGRKGQERSRTHLTVPAGSTQLPLCPGLFPCGVAPGLCLTPEQLCDGIPDCPQGEDELD
    • 1672-1672: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
    • 2180-2315: LFPRNWDDLDPAVWTFGRMVQARFVRVWPHDVHHSDVPLQVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLALSSAQPGQLLHWPREGLAETEHWPPGQE → VSPAQGRWGQQPTMPFCGFHSLCPQGPSSVPEGHGLHSMLVEYLVSSRDCALWSRGLGATVTWMLETIQVAQTQGRYVKPARERGWGDTKFTEGLREPRPTHVFVESSLGTALPSGGLHPSRRQTARSGRNQSVLC
    • 2316-5147: Missing

Sequence caution

The sequence BAC98376.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_0352581-1123in isoform 2
Alternative sequenceVSP_0352591124-1127in isoform 2
Compositional bias1530-1544Pro residues
Compositional bias1545-1559Polar residues
Alternative sequenceVSP_0352601640in isoform 2
Alternative sequenceVSP_0352611672in isoform 2
Alternative sequenceVSP_0352622180-2315in isoform 2
Compositional bias2312-2326Polar residues
Alternative sequenceVSP_0352632316-5147in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB111888
EMBL· GenBank· DDBJ
BAC98376.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC004877
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF459635
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF495712
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF459640
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BN000852
EMBL· GenBank· DDBJ
CAJ43920.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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