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UniProtKB - A1Z8X5 (A1Z8X5_DROME)

Entry version 105 (10 Feb 2021)
Sequence version 2 (03 Mar 2009)
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Protein

Peptidase_M28 domain-containing protein

Gene

CG30049-PA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • proteolysis Source: GO_Central
Complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database

More...MEROPSi		M28.A09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidase_M28 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG30049-PAImported
Synonyms:Dmel\CG30049Imported
ORF Names:CG30049Imported, Dmel_CG30049Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0050049, CG30049

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 56HelicalSequence analysisAdd BLAST24
Transmembranei385 – 404HelicalSequence analysisAdd BLAST20
Transmembranei424 – 447HelicalSequence analysisAdd BLAST24
Transmembranei459 – 481HelicalSequence analysisAdd BLAST23
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Transmembranei520 – 539HelicalSequence analysisAdd BLAST20
Transmembranei559 – 580HelicalSequence analysisAdd BLAST22
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Transmembranei618 – 642HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A1Z8X5

PRoteomics IDEntifications database

More...PRIDEi		A1Z8X5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0050049, Expressed in midgut and 13 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1Z8X5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1Z8X5, DM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 344Peptidase_M28InterPro annotationAdd BLAST195

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2194, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007536_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A1Z8X5

Identification of Orthologs from Complete Genome Data

More...OMAi		MEWPSLF

Database of Orthologous Groups

More...OrthoDBi		248924at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A1Z8X5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007484, Peptidase_M28

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04389, Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1Z8X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVLTDGDKE GFSDTALYHV LSKEKKLKRR LPWYYAPSFL LLWVALFYAI 
        60         70         80         90        100
VLPLFYRLPD RVTMADEPLK PGQFVGERAQ KILYELDRIG PKVVGSTANE 
       110        120        130        140        150
VTTVAFLLNE VEKIRSEMRG DLFHLEVDVQ QPTGSYVVGT MTSIYQGIQN 
       160        170        180        190        200
VVVKLSTASS NSSSYLLINS HFDTKPGSPG AGDDGTMVVV MLEVLRQMSI 
       210        220        230        240        250
SESEFMHPIV FLFNGAEENP LQASHGFITQ HKWAPNCKAV INLEVGGNGG 
       260        270        280        290        300
RDILFQSGPN NPWLVKYYKQ HSKHPFASTL AEEIFQFGIL PSDTDFRIFR 
       310        320        330        340        350
DYGNIPGLDI AQFSNGYVYH TAFDSFDVVP GRAVQNTGEN ILSLVRALSN 
       360        370        380        390        400
ASELYNTNEH SAGHAVFFDF LGLFFVTYTE NTGIILNYCF AVASVFLVGF 
       410        420        430        440        450
SLWRMSCVSE VSAGRISILF ASHLGLHLAG CLLCIGLPLV MSILYDVSDR 
       460        470        480        490        500
TMTYYSNNWL VIGLYICPAI IGLVLPSTLY HSFKSDDKIS HPYQMYVGLH 
       510        520        530        540        550
AHCVVLSILT IALTAIGLRI PYMCMISLFL YILSLLINLL TTLHDRGYYW 
       560        570        580        590        600
VLTVQISQLF QYVYFCYLFY IFLVIFFPAM GRNRDSANPD MLIALICAVG 
       610        620        630        640        650
TFFALGFVVP LINMFRWSTY LLICLGVVTF ILSMISITGV GFPYRPKTSV 
       660        670        680        690        700
MRVNFLQTRR MFYEYDGSLS VNDSGYYFDY QDRRALRPLK DYAVNLTGLT 
       710        720        730        740        750
SVDGYCDRYV MCGIPCFWSS WCRGISSAAW LPRDEEVTVP GNLELNFLNK 
       760        770        780        790        800
TLSKSGSSAR FEFELAGPPH MGLYIRPLDG VAVEDWSFIR TMLDQPEKYS 
       810        820        830        840        850
PPYQIYFSYG VDSSPFKFHI EFVKSDGQLD GPIFELGVVG HYVNQDFERD 
       860        870 
ETTLRFIADL PDFVYTMEWP SLFMRYIF
Length:878
Mass (Da):99,385
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7382C8F977B292D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68673.3

NCBI Reference Sequences

More...RefSeqi		NP_725142.3, NM_165888.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0087906; FBpp0087017; FBgn0050049

Database of genes from NCBI RefSeq genomes

More...GeneIDi		246416

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG30049

UCSC genome browser

More...UCSCi		CG30049-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68673.3
RefSeqiNP_725142.3, NM_165888.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiM28.A09

Proteomic databases

PaxDbiA1Z8X5
PRIDEiA1Z8X5

Genome annotation databases

EnsemblMetazoaiFBtr0087906; FBpp0087017; FBgn0050049
GeneIDi246416
KEGGidme:Dmel_CG30049
UCSCiCG30049-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0050049, CG30049

Phylogenomic databases

eggNOGiKOG2194, Eukaryota
GeneTreeiENSGT00530000063839
HOGENOMiCLU_007536_2_0_1
InParanoidiA1Z8X5
OMAiMEWPSLF
OrthoDBi248924at2759
PhylomeDBiA1Z8X5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		246416, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		246416

Gene expression databases

BgeeiFBgn0050049, Expressed in midgut and 13 other tissues
ExpressionAtlasiA1Z8X5, baseline and differential
GenevisibleiA1Z8X5, DM

Family and domain databases

InterProiView protein in InterPro
IPR007484, Peptidase_M28
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z8X5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z8X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: March 3, 2009
Last modified: February 10, 2021
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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