Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 92 (12 Aug 2020)
Sequence version 1 (09 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NAD-specific glutamate dehydrogenase

Gene

gdh

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible conversion of L-glutamate to 2-oxoglutarate. Highly specific for NAD.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by unphosphorylated GarA. Stimulated by manganese and magnesium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=45 mM for ammonium1 Publication

    pH dependencei

    Optimum pH is 8.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei816By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNAD

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    GCF_000015005:MSMEG_4699-MONOMER
    MSME246196:G1H7P-4668-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.4.1.2, 3512

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    NAD-specific glutamate dehydrogenase (EC:1.4.1.2)
    Short name:
    NAD-GDH
    Alternative name(s):
    NAD(+)-dependent glutamate dehydrogenase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gdh
    Ordered Locus Names:MSMEG_4699, MSMEI_4582
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006158 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000757 Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004195351 – 1594NAD-specific glutamate dehydrogenaseAdd BLAST1594

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A0R1C2

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with (unphosphorylated) GarA.

    1 Publication

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    A0R1C2, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    246196.MSMEI_4582

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG2902, Bacteria

    KEGG Orthology (KO)

    More...
    KOi
    K15371

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HLHINTA

    Database of Orthologous Groups

    More...
    OrthoDBi
    79339at2

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036291, NAD(P)-bd_dom_sf
    IPR028971, NAD-GDH
    IPR007780, NAD_Glu_DH_bac

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43403, PTHR43403, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF05088, Bac_GDH, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF036761, GDH_Mll4104, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735, SSF51735, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0R1C2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MIRRLSVAFL STYRGPQADA PGVTSTGPLA VAAHDDLVSD DLVAAHYRLA
    60 70 80 90 100
    SMRAPGETKA AVYPGDAGSG AALQIVTDQA PMLVDSVTVL LHRHGIAYTA
    110 120 130 140 150
    IMNPVFRVRR GLDGELLDVR PAAEAAPGDG ADECWILVPI TAAADGEALT
    160 170 180 190 200
    EATRLVPGIL AEARQIGLDS GAMIAALHGL ANDLATDLEG HFPNAERKEV
    210 220 230 240 250
    AALLRWLADG HFVLLGYQQC VVGDGNAEVD PASRLGVLRL RNDVLPPLTD
    260 270 280 290 300
    SDDLLVLAQA TMPSYLRYGA YPYIVVVRES PGASRVIEHR FVGLFTVAAM
    310 320 330 340 350
    NANALEIPLI SRRVEEALAM AHRDPSHPGQ LLRDIIQTIP RPELFALSSK
    360 370 380 390 400
    QLLEMALAVV DLGSRRRTLL FLRADHLAHF VSCLVYLPRD RYTTAVRLEM
    410 420 430 440 450
    QDILVRELGG AGIDYSARVS ESPWAVVHFT VRLPEGTAAD SVDTSLENES
    460 470 480 490 500
    RIQDLLTEAT RNWGDRMISA AAAASISPAA LEHYAHAFPE DYKQAFAPQD
    510 520 530 540 550
    AIADISLIEA LQDDSVKLVL ADTAEDRVWK LTWYLGGHSA SLSELLPMLQ
    560 570 580 590 600
    SMGVVVLEER PFTLRRTDGL PVWIYQFKIS PHPSIPHAPD AEAQRDTAQR
    610 620 630 640 650
    FADAVTAIWH GRVEIDRFNE LVMRAGLTWQ QVVVLRAYAK YLRQAGFPYS
    660 670 680 690 700
    QSHIESVLNE NPHTTRSLID LFEALFDPSQ ETDGRRDAQG AAAAVAADID
    710 720 730 740 750
    ALVSLDTDRV LRAFANLIEA TLRTNYFVAR PDSARARNVL AFKLNPLVIK
    760 770 780 790 800
    ELPLPRPKFE IFVYSPRVEG VHLRFGFVAR GGLRWSDRRE DFRTEILGLV
    810 820 830 840 850
    KAQAVKNAVI VPVGAKGGFV VKRPPTLTGD AAADREATRA EGVECYRLFI
    860 870 880 890 900
    SGLLDVTDNV DKATGAVVTP PEVVRRDGED AYLVVAADKG TATFSDIANE
    910 920 930 940 950
    VAKSYGFWLG DAFASGGSIG YDHKAMGITA KGAWESVKRH FREMGVDTQT
    960 970 980 990 1000
    QDFTVVGIGD MSGDVFGNGM LLSKHIRLVA AFDHRDIFLD PNPDAGRSWD
    1010 1020 1030 1040 1050
    ERKRLFDLPR SSWADYDKSL ISEGGGVYSR QQKSIPISPQ VRTALGLDAD
    1060 1070 1080 1090 1100
    VEELTPPALI KAILKAPVDL LWNGGIGTYI KAETEADADV GDRANDQIRV
    1110 1120 1130 1140 1150
    CGNQVRAKVI GEGGNLGVTA LGRIEFDLAG GRINTDALDN SAGVDCSDHE
    1160 1170 1180 1190 1200
    VNIKILIDSA VTAGKVTPEE RTELLLSMTD EVGELVLADN RDQNDLMGTS
    1210 1220 1230 1240 1250
    RANAASLLSV HARMIKDLVD NRGLNRELEA LPSEKEIRRR ADAGIGLTSP
    1260 1270 1280 1290 1300
    ELATLMAHVK LALKDDVLAS DLPDQEVFAS RLPYYFPTRL REELHGEIRS
    1310 1320 1330 1340 1350
    HQLRREIITT MLVNDLVDTA GISYAYRITE DVGVGPVDAV RSYVAINAIF
    1360 1370 1380 1390 1400
    GIGDVWRRIR AAGDAGVPTS VTDRMTLDLR RLVDRAGRWL LNYRPQPLAV
    1410 1420 1430 1440 1450
    GAEINRFGAK VAALTPRMSE WLRGDDKAIV SKEAGDFASH GVPEDLAYHI
    1460 1470 1480 1490 1500
    ATGLYQYSLL DVIDIADIVD REPDEVADTY FALMDHLGAD ALLTAVSRLS
    1510 1520 1530 1540 1550
    RDDRWHSLAR LAIRDDIYGS LRALCFDVLA VGEPDENGEE KIAEWETTNS
    1560 1570 1580 1590
    SRVTRARRTL TEIYKDGEQD LATLSVAARQ IRSMTRTSGT GTTG
    Length:1,594
    Mass (Da):174,095
    Last modified:January 9, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B3C5F350E829840
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AFP41034 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP000480 Genomic DNA Translation: ABK72988.1
    CP001663 Genomic DNA Translation: AFP41034.1 Different initiation.

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_011730019.1, NZ_SIJM01000004.1
    YP_888960.1, NC_008596.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ABK72988; ABK72988; MSMEG_4699
    AFP41034; AFP41034; MSMEI_4582

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    msb:LJ00_23235
    msg:MSMEI_4582
    msm:MSMEG_4699

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|246196.19.peg.4589

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000480 Genomic DNA Translation: ABK72988.1
    CP001663 Genomic DNA Translation: AFP41034.1 Different initiation.
    RefSeqiWP_011730019.1, NZ_SIJM01000004.1
    YP_888960.1, NC_008596.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    IntActiA0R1C2, 2 interactors
    STRINGi246196.MSMEI_4582

    Proteomic databases

    PRIDEiA0R1C2

    Genome annotation databases

    EnsemblBacteriaiABK72988; ABK72988; MSMEG_4699
    AFP41034; AFP41034; MSMEI_4582
    KEGGimsb:LJ00_23235
    msg:MSMEI_4582
    msm:MSMEG_4699
    PATRICifig|246196.19.peg.4589

    Phylogenomic databases

    eggNOGiCOG2902, Bacteria
    KOiK15371
    OMAiHLHINTA
    OrthoDBi79339at2

    Enzyme and pathway databases

    BioCyciGCF_000015005:MSMEG_4699-MONOMER
    MSME246196:G1H7P-4668-MONOMER
    BRENDAi1.4.1.2, 3512

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291, NAD(P)-bd_dom_sf
    IPR028971, NAD-GDH
    IPR007780, NAD_Glu_DH_bac
    PANTHERiPTHR43403, PTHR43403, 1 hit
    PfamiView protein in Pfam
    PF05088, Bac_GDH, 1 hit
    PIRSFiPIRSF036761, GDH_Mll4104, 1 hit
    SUPFAMiSSF51735, SSF51735, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHE2_MYCS2
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0R1C2
    Secondary accession number(s): I7GDY4
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: January 9, 2007
    Last modified: August 12, 2020
    This is version 92 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again