A0A843IXJ2 · A0A843IXJ2_9EURY

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Binding site36Mg2+ (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site65Mg2+ (UniProtKB | ChEBI)
Binding site66substrate
Binding site140-143substrate
Binding site161substrate
Binding site166-167substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      J6104_01395

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RGIG10369
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanomicrobiales > Methanomicrobiaceae > Methanomicrobium

Accessions

  • Primary accession
    A0A843IXJ2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    183
  • Mass (Da)
    20,248
  • Last updated
    2021-09-29 v1
  • Checksum
    24C42015645069EA
MKEITVVTGNENKAREVAAFFEGICSVDHINMDLTEIQSDDVGQIARFKAHEAYELLKKPVIVDDTGFFINAFKGFPGAYSAYVLDTIGISGILSLLAGLPDRNGTFVTAIAYADSEGIFVFEGEVKGKVTKVPRGTNGFGYDPIFEYEGRTFAEIGLKEKSMISHRARALTEFKKWYVQNRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGDDN010000048
EMBL· GenBank· DDBJ
MBP5082871.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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