A0A832ZLH2 · A0A832ZLH2_9CREN
- ProteinSignal recognition particle 54 kDa protein
- Genesrp54
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Catalytic activity
- GTP + H2O = GDP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | signal recognition particle | |
Molecular Function | 7S RNA binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSignal recognition particle 54 kDa protein
- EC number
- Short namesSRP54
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Desulfurococcales
Accessions
- Primary accessionA0A832ZLH2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.
Keywords
- Cellular component
Interaction
Subunit
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-84 | Signal recognition particle SRP54 helical bundle | ||||
Sequence: MKGLEGLREAVRKLLRSSSSYEKAVNELIRDLQRTLLKADVNVKLVFQLTRSVKKRALEEKPPPGITRREWVVKILLDELVKLF | ||||||
Domain | 97-298 | AAA+ ATPase | ||||
Sequence: KPYIIMLVGIQGSGKTTSAAKLAYYYAKRGFKVGLVCADTFRPAAYIQLKQLGEKINIPVYGREGEKNSIKLALEGVEYFKKQNFDIIIIDTAGRHKEEKGLLEEMKNIAKAIKPDEVMLIIDASIGQQAYIQAKAFHEATPIGSIMITKMDGTAKGGGALSAVAATGAKIKFIGTGELIEDIERFSPKGFVSRLLGLGDIE | ||||||
Domain | 98-293 | SRP54-type proteins GTP-binding | ||||
Sequence: PYIIMLVGIQGSGKTTSAAKLAYYYAKRGFKVGLVCADTFRPAAYIQLKQLGEKINIPVYGREGEKNSIKLALEGVEYFKKQNFDIIIIDTAGRHKEEKGLLEEMKNIAKAIKPDEVMLIIDASIGQQAYIQAKAFHEATPIGSIMITKMDGTAKGGGALSAVAATGAKIKFIGTGELIEDIERFSPKGFVSRLLG |
Domain
Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
Sequence similarities
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)49,825
- Last updated2021-09-29 v1
- ChecksumD1C0D819100F0109