A0A832ZLH2 · A0A832ZLH2_9CREN

  • Protein
    Signal recognition particle 54 kDa protein
  • Gene
    srp54
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

144150100150200250300350400
TypeIDPosition(s)Description
Binding site105-112GTP (UniProtKB | ChEBI)
Binding site187-191GTP (UniProtKB | ChEBI)
Binding site245-248GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle 54 kDa protein
  • EC number
  • Short names
    SRP54

Gene names

    • Name
      srp54
    • ORF names
      EYH40_04190

Organism names

Accessions

  • Primary accession
    A0A832ZLH2

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-84Signal recognition particle SRP54 helical bundle
Domain97-298AAA+ ATPase
Domain98-293SRP54-type proteins GTP-binding

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    441
  • Mass (Da)
    49,825
  • Last updated
    2021-09-29 v1
  • Checksum
    D1C0D819100F0109
MKGLEGLREAVRKLLRSSSSYEKAVNELIRDLQRTLLKADVNVKLVFQLTRSVKKRALEEKPPPGITRREWVVKILLDELVKLFGGLEEPNVLPKKKPYIIMLVGIQGSGKTTSAAKLAYYYAKRGFKVGLVCADTFRPAAYIQLKQLGEKINIPVYGREGEKNSIKLALEGVEYFKKQNFDIIIIDTAGRHKEEKGLLEEMKNIAKAIKPDEVMLIIDASIGQQAYIQAKAFHEATPIGSIMITKMDGTAKGGGALSAVAATGAKIKFIGTGELIEDIERFSPKGFVSRLLGLGDIEALLDKIREAQLEEELAKKQYEILKSGRITLRDLYYQIKSIRRMGPLSKLLQMIPGFSLTLPSEDQLKLTEEKMDKWLAIINSMTYEELEKPSKIDRSRMRRIAIGSGTTIEDVKELLKYYEIMNKMLKQIKRRKGLLRKLHIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQVH01000108
EMBL· GenBank· DDBJ
HIQ03602.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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