A0A814F8T7 · A0A814F8T7_ADIRI

Function

function

Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentphagophore assembly site membrane
Biological Processautophagy
Biological Processlipid transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 9

Gene names

    • ORF names
      EDS130_LOCUS16073
      , XAT740_LOCUS12114

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Adinetida > Adinetidae > Adineta

Accessions

  • Primary accession
    A0A814F8T7

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Preautophagosomal structure membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-89Helical
Transmembrane130-154Helical
Transmembrane288-309Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region612-657Disordered

Sequence similarities

Belongs to the ATG9 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    738
  • Mass (Da)
    85,562
  • Last updated
    2021-09-29 v1
  • Checksum
    B985CD546A518A76
MDYRTQNNEENDGSDENEQVLSPFVHFETHEDENNSEKQSKWSHQQDLDDFFVQVYQYHQKHGFFCIAISEIFGLIQFVFIVSFTILLVQCVDYPLLFRSSPAARNITDKIQIHQVIQSPKQCLHNMYRITNWCLILSIIYWIYRFACAVYHLASYFNIRSFYTQALDIKPHDLPNMTWHEVQQRLLIAQRTHHLCIHKSNLTELDIHNRLLRFKNYEVALVNKGVLPLRVHVPFLGDIISFTAGFKFNLRLILFSGPCAPFDQRWHLRQEYKIHSQREVLANQLSRLILLYGIANLLLSPFIFIWQVLNLFYGYTELVRREPGVLGSRRWSNYGRLYLRHFNELDHSLNQRLNRGYRPAMSYMTSFVNYSIVETAKFVSFTAGAIFAVLIVLTIVDEDVLNVEHMLTLMTGLGVLLGVCRSLIPDENAVFDPEQMLQLVLAHTHYQPDSWKDHAHTDYVQAGFGQIFQLKYVYFLEELFSPFVTPILLCFHLRRKSLQIIDFLRNYTVDVQGVGDVCSFAQLDVAKHGDLKWFAPVRAKQGNDAGITNDGKLELSLMHFHHTNPKWQMPKQCEAYLEKIQERAVENMQTSSVLQQSLGQVQRSLYNDAQSTSSMISKARNDPNTYSHFASPNHTSIQMSSQYPSTSMPQTSASQADLPYRSPAPFGVLSKIHSQMFDSSNSTFLSGSMAPLQTFSSAAQLDMNISCLFMHELRHKYKHGEYEELEHINEDHDDDTKC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJNOR010000679
EMBL· GenBank· DDBJ
CAF0979681.1
EMBL· GenBank· DDBJ
Genomic DNA
CAJNOJ010000069
EMBL· GenBank· DDBJ
CAF1024576.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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