A0A7X1BUA1 · A0A7X1BUA1_9ENTR
- ProteinXaa-Pro dipeptidase
- GenepepQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Splits dipeptides with a prolyl residue in the C-terminal position.
Catalytic activity
- Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 246 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 257 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 257 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 339 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 384 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 423 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 423 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aminopeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metalloexopeptidase activity | |
Molecular Function | phosphoric triester hydrolase activity | |
Molecular Function | proline dipeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameXaa-Pro dipeptidase
- EC number
- Short namesX-Pro dipeptidase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Citrobacter > Citrobacter freundii complex
Accessions
- Primary accessionA0A7X1BUA1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-157 | Xaa-Pro dipeptidase N-terminal | ||||
Sequence: LYKNHIVTLKERARDALERFKLDALLIHSGELVNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEIEIIALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHY | ||||||
Domain | 168-430 | Peptidase M24 | ||||
Sequence: ACMREAQKMAVNGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPSEIRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEELALIATMKAGTSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVVHE |
Sequence similarities
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)50,165
- Last updated2021-06-02 v1
- Checksum51D76B64049F6D8A