A0A7R7TBX0 · A0A7R7TBX0_THETH
- ProteinLeucine--tRNA ligase
- GeneleuS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids878 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aminoacyl-tRNA editing activity | |
Molecular Function | ATP binding | |
Molecular Function | leucine-tRNA ligase activity | |
Molecular Function | metal ion binding | |
Biological Process | leucyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus
Accessions
- Primary accessionA0A7R7TBX0
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-176 | Methionyl/Leucyl tRNA synthetase | ||||
Sequence: VLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYENIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRC | ||||||
Motif | 42-52 | 'HIGH' region | ||||
Sequence: PYPSGDLHMGH | ||||||
Domain | 221-406 | Leucyl-tRNA synthetase editing | ||||
Sequence: RAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLE | ||||||
Domain | 419-579 | Aminoacyl-tRNA synthetase class Ia | ||||
Sequence: LRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLA | ||||||
Domain | 580-635 | Leucyl-tRNA synthetase | ||||
Sequence: WTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLENVRKMGAELRPHEDGTLHLWKP | ||||||
Domain | 718-842 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding | ||||
Sequence: DRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVA |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length878
- Mass (Da)101,089
- Last updated2021-09-29 v1
- ChecksumD507E7DB1667B051
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP024270 EMBL· GenBank· DDBJ | BCP65283.1 EMBL· GenBank· DDBJ | Genomic DNA |