A0A7N9ICN8 · A0A7N9ICN8_MACFA
- ProteinAldehyde dehydrogenase 1A1
- GeneALDH1A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids481 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (E)-4-hydroxynon-2-enal + H2O + NAD+ = (E)-4-hydroxynon-2-enoate + 2 H+ + NADHThis reaction proceeds in the forward direction.
- 13-cis-retinal + H2O + NAD+ = 13-cis-retinoate + 2 H+ + NADHThis reaction proceeds in the forward direction.
- 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADHThis reaction proceeds in the forward direction.
- 9-cis-retinal + H2O + NAD+ = 9-cis-retinoate + 2 H+ + NADHThis reaction proceeds in the forward direction.
- H2O + NAD+ + propanal = 2 H+ + NADH + propanoateThis reaction proceeds in the forward direction.
- H2O + hexanal + NAD+ = 2 H+ + hexanoate + NADHThis reaction proceeds in the forward direction.
- H2O + malonaldehyde + NAD+ = 3-oxopropanoate + 2 H+ + NADHThis reaction proceeds in the forward direction.
Pathway
Cofactor metabolism; retinol metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 249 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldehyde dehydrogenase 1A1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A7N9ICN8
Proteomes
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-472 | Aldehyde dehydrogenase | ||||
Sequence: WHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length481
- Mass (Da)52,659
- Last updated2021-06-02 v1
- Checksum1ED06A5191A69A08
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q4R5G3 | Q4R5G3_MACFA | ALDH1A1 | 501 | ||
A0A7N9C970 | A0A7N9C970_MACFA | ALDH1A1 | 495 | ||
A0A7N9CC80 | A0A7N9CC80_MACFA | ALDH1A1 | 527 | ||
A0A7N9CLZ3 | A0A7N9CLZ3_MACFA | ALDH1A1 | 463 | ||
A0A2K5WPH2 | A0A2K5WPH2_MACFA | ALDH1A1 | 298 | ||
A0A2K5WP74 | A0A2K5WP74_MACFA | ALDH1A1 | 230 | ||
A0A7N9CZ59 | A0A7N9CZ59_MACFA | ALDH1A1 | 511 |
Keywords
- Technical term