A0A7N9ICN8 · A0A7N9ICN8_MACFA

Function

Catalytic activity

  • (E)-4-hydroxynon-2-enal + H2O + NAD+ = (E)-4-hydroxynon-2-enoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
  • 13-cis-retinal + H2O + NAD+ = 13-cis-retinoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
  • 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
  • 4-aminobutanal + H2O + NAD+ = 4-aminobutanoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.2.1.19 (UniProtKB | ENZYME | Rhea)
  • 9-cis-retinal + H2O + NAD+ = 9-cis-retinoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
  • H2O + NAD+ + propanal = 2 H+ + NADH + propanoate
    This reaction proceeds in the forward direction.
  • H2O + hexanal + NAD+ = 2 H+ + hexanoate + NADH
    This reaction proceeds in the forward direction.
  • H2O + malonaldehyde + NAD+ = 3-oxopropanoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
  • acetaldehyde + H2O + NAD+ = acetate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinal + H2O + NAD+ = all-trans-retinoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.2.1.36 (UniProtKB | ENZYME | Rhea)
  • an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • benzaldehyde + H2O + NAD+ = benzoate + 2 H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.2.1.28 (UniProtKB | ENZYME | Rhea)

Pathway

Cofactor metabolism; retinol metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site249

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde dehydrogenase 1A1
  • EC number
  • Alternative names
    • 3-deoxyglucosone dehydrogenase
    • ALDH-E1
    • ALHDII
    • Aldehyde dehydrogenase family 1 member A1
    • Aldehyde dehydrogenase, cytosolic
    • Retinal dehydrogenase 1

Gene names

    • Name
      ALDH1A1

Organism names

Accessions

  • Primary accession
    A0A7N9ICN8

Proteomes

Subcellular Location

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-472Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    52,659
  • Last updated
    2021-06-02 v1
  • Checksum
    1ED06A5191A69A08
MKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q4R5G3Q4R5G3_MACFAALDH1A1501
A0A7N9C970A0A7N9C970_MACFAALDH1A1495
A0A7N9CC80A0A7N9CC80_MACFAALDH1A1527
A0A7N9CLZ3A0A7N9CLZ3_MACFAALDH1A1463
A0A2K5WPH2A0A2K5WPH2_MACFAALDH1A1298
A0A2K5WP74A0A2K5WP74_MACFAALDH1A1230
A0A7N9CZ59A0A7N9CZ59_MACFAALDH1A1511

Keywords

Genome annotation databases

Similar Proteins

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