A0A7J8DUE5 · A0A7J8DUE5_MOLMO
- ProteinNibrin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids634 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | Mre11 complex | |
Cellular Component | PML body | |
Molecular Function | damaged DNA binding | |
Biological Process | DNA duplex unwinding | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | meiotic cell cycle | |
Biological Process | mitotic G2 DNA damage checkpoint signaling | |
Biological Process | telomere maintenance |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNibrin
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Molossidae > Molossus
Accessions
- Primary accessionA0A7J8DUE5
Proteomes
Subcellular Location
Interaction
Subunit
Component of the MRN complex.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-82 | FHA | ||||
Sequence: YVVGRKNCGILIENDQSISRSHAVLTACFLRTGQSQTQEIPVLTIKDTSKYGTFVNKEKM | ||||||
Region | 387-486 | Disordered | ||||
Sequence: SRMEQNLRMPSQAPSTVKEPPKISSDNTTVGSNAQLRTKVPDYQLSPVMLPSVSRGRDLASQQPKTNSIRNYFQPSTKKRERNEENQDTSSSKSARTETS | ||||||
Compositional bias | 391-426 | Polar residues | ||||
Sequence: QNLRMPSQAPSTVKEPPKISSDNTTVGSNAQLRTKV | ||||||
Compositional bias | 442-460 | Polar residues | ||||
Sequence: GRDLASQQPKTNSIRNYFQ | ||||||
Compositional bias | 461-477 | Basic and acidic residues | ||||
Sequence: PSTKKRERNEENQDTSS |
Sequence similarities
Belongs to the Nibrin family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)71,296
- Last updated2021-04-07 v1
- Checksum31A087E0A4E49C4B
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J8DUB1 | A0A7J8DUB1_MOLMO | HJG59_012843 | 753 | ||
A0A7J8DU96 | A0A7J8DU96_MOLMO | HJG59_012843 | 603 | ||
A0A7J8DTS6 | A0A7J8DTS6_MOLMO | HJG59_012843 | 667 | ||
A0A7J8DU00 | A0A7J8DU00_MOLMO | HJG59_012843 | 379 | ||
A0A7J8DU14 | A0A7J8DU14_MOLMO | HJG59_012843 | 762 | ||
A0A7J8DU29 | A0A7J8DU29_MOLMO | HJG59_012843 | 672 | ||
A0A7J8DUQ6 | A0A7J8DUQ6_MOLMO | HJG59_012843 | 461 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 391-426 | Polar residues | ||||
Sequence: QNLRMPSQAPSTVKEPPKISSDNTTVGSNAQLRTKV | ||||||
Compositional bias | 442-460 | Polar residues | ||||
Sequence: GRDLASQQPKTNSIRNYFQ | ||||||
Compositional bias | 461-477 | Basic and acidic residues | ||||
Sequence: PSTKKRERNEENQDTSS |
Keywords
- Technical term