A0A7J8DUE5 · A0A7J8DUE5_MOLMO

Function

function

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentMre11 complex
Cellular ComponentPML body
Molecular Functiondamaged DNA binding
Biological ProcessDNA duplex unwinding
Biological Processdouble-strand break repair via homologous recombination
Biological Processmeiotic cell cycle
Biological Processmitotic G2 DNA damage checkpoint signaling
Biological Processtelomere maintenance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nibrin

Gene names

    • ORF names
      HJG59_012843

Organism names

Accessions

  • Primary accession
    A0A7J8DUE5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the MRN complex.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain23-82FHA
Region387-486Disordered
Compositional bias391-426Polar residues
Compositional bias442-460Polar residues
Compositional bias461-477Basic and acidic residues

Sequence similarities

Belongs to the Nibrin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    634
  • Mass (Da)
    71,296
  • Last updated
    2021-04-07 v1
  • Checksum
    31A087E0A4E49C4B
MWKLVPEADSAREPYRLLTDVEYVVGRKNCGILIENDQSISRSHAVLTACFLRTGQSQTQEIPVLTIKDTSKYGTFVNKEKMQNGLSQTLQTGDRVAFGVFESKFRVEYEPLVACPSCLDVSWKTALHQALLQLGGLTVNSWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVQSKKQLPQIESFYPPIDEPAIGSKNIDLSGRQERKQIFKGKTFVFLSAKQHKKLSPAVVFGGGVARLITEENEEEESFFLASGTCVIDIGITNSQTLISDSQKKWIHSIMDMLQRQGLRPIPEAEIGLAVIFITTENYCDPQAQPNTGSRMMSPGLSLSQGLSVKEQLMSSAPMNTVTYVADTESEQADTCMDFSTRPKEIKISRMEQNLRMPSQAPSTVKEPPKISSDNTTVGSNAQLRTKVPDYQLSPVMLPSVSRGRDLASQQPKTNSIRNYFQPSTKKRERNEENQDTSSSKSARTETSCFFLEETQPATPSVWRNEEQHLPESEPMGKNPDNVFIDTESKSTVKNPASKFFSTEKLRSEKRKIDDVAIEDEVLEELLKETKPELEIEVKGLKQEEDVKFRKMPRLVIETNGSFNDETLPERNKISFSSRLVHCSQWPPLCLDVLCF

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J8DUB1A0A7J8DUB1_MOLMOHJG59_012843753
A0A7J8DU96A0A7J8DU96_MOLMOHJG59_012843603
A0A7J8DTS6A0A7J8DTS6_MOLMOHJG59_012843667
A0A7J8DU00A0A7J8DU00_MOLMOHJG59_012843379
A0A7J8DU14A0A7J8DU14_MOLMOHJG59_012843762
A0A7J8DU29A0A7J8DU29_MOLMOHJG59_012843672
A0A7J8DUQ6A0A7J8DUQ6_MOLMOHJG59_012843461

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias391-426Polar residues
Compositional bias442-460Polar residues
Compositional bias461-477Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACASF010000016
EMBL· GenBank· DDBJ
KAF6426609.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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