A0A7J5EMV5 · A0A7J5EMV5_UNCBA

  • Protein
    Biosynthetic arginine decarboxylase
  • Gene
    speA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the biosynthesis of agmatine from arginine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site282-292substrate
Active site499Proton donor

GO annotations

AspectTerm
Molecular Functionarginine decarboxylase activity
Molecular Functionmetal ion binding
Biological Processarginine catabolic process
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Biosynthetic arginine decarboxylase
  • EC number
  • Short names
    ADC

Gene names

    • Name
      speA
    • ORF names
      F9K28_05765

Organism names

Accessions

  • Primary accession
    A0A7J5EMV5

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue100N6-(pyridoxal phosphate)lysine

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain92-342Orn/DAP/Arg decarboxylase 2 N-terminal
Domain367-448Arginine decarboxylase helical bundle
Domain575-628Arginine decarboxylase C-terminal helical

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    71,262
  • Last updated
    2021-04-07 v1
  • Checksum
    429824800DE36303
MRKWRAEDSSELYNVHGWGVSYFGVNEAGNVTVQPRKNKGPEIDLKQVIDEVVARDVSLPVLLRFPDILDDRIEKIALCFDKAGADYGYNGQYYSVYPIKVNQQRPVVEELVRYGERVNIGLEAGSKPELHAVLAIMGNPDALIICNGYKDEDYIELALLAQKMGKQIYVVVEKLNELRLINTISKRLGVRPNIGIRIKLAASGSGKWEESGGDNSKFGLNPAELLEAVDYARNENLLDCLRLIHFHLGSQITNIRRIKSGLREVSEYYVELMKQGCNIEFVDIGGGLGVDYDGSRSSYASSINYSIQEYANDAVATIVDAATRNSLPHPNLITESGRALTAHHSVLVFNVLETAKVPEWGETDTADDTDHELVREMHGILQNISPRAMFESWHDAQQVREEALDRFSLGLVDLAARAKVEKLYWSVARAVYDLSKELKNPPEELKPLQRLLAEKYFCNFSLFQSLPDSWAIDQLFPIMPIHRLCEKPTRMATLQDITCDSDGKVDRFIGGRDYRQTLPLHPMNSEPYYLAVFLVGAYQEILGDLHNLFGDTNAVHIVIKNNTYHIENIIDGETVADVLDYVQFDAKRLVRTMETWVNSSVQDGRISNHEGREFLNIYRSGLYGYTYLEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WBUM01000010
EMBL· GenBank· DDBJ
KAB2894245.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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