A0A7J3XM07 · A0A7J3XM07_9ARCH
- ProteinOrotate phosphoribosyltransferase
- GenepyrE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids436 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 346 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 350 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: K | ||||||
Binding site | 372-380 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: DDLTTTGET | ||||||
Binding site | 376 | orotate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 404 | orotate (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | orotate phosphoribosyltransferase activity | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT ; OPRTase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Nitrososphaerota > Nitrososphaeria
Accessions
- Primary accessionA0A7J3XM07
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-242 | Orotidine 5'-phosphate decarboxylase | ||||
Sequence: ILCISLDVKRKGETRKEYLERLKQLVERTAPYTVAFKINENYTRHLSVEDHQEITQLCKSLGTLTIYDCKLSDITSTATTGIGIVKDMGYDGLTVNPIFGNLSQIAEVAHELGIALFSVTLPSNPESSRLFKLDIGDKKLFEIFAEDAKISKVDGLVVSATETASADDITTIRKAVGEEPIILFPGIGAQSGDMEKAIVHGGWNVLLNVGRSIAESPEPERAAAEY |
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length436
- Mass (Da)47,932
- Last updated2021-04-07 v1
- Checksum3A83CD6B3BEDEF31