A0A7J3XM07 · A0A7J3XM07_9ARCH

  • Protein
    Orotate phosphoribosyltransferase
  • Gene
    pyrE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site3465-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3505-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site372-3805-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site376orotate (UniProtKB | ChEBI)
Binding site404orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      ENM95_04635
      , ENV33_02720

Organism names

Accessions

  • Primary accession
    A0A7J3XM07

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-242Orotidine 5'-phosphate decarboxylase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    436
  • Mass (Da)
    47,932
  • Last updated
    2021-04-07 v1
  • Checksum
    3A83CD6B3BEDEF31
MSFLKRYAELRRQKGSILCISLDVKRKGETRKEYLERLKQLVERTAPYTVAFKINENYTRHLSVEDHQEITQLCKSLGTLTIYDCKLSDITSTATTGIGIVKDMGYDGLTVNPIFGNLSQIAEVAHELGIALFSVTLPSNPESSRLFKLDIGDKKLFEIFAEDAKISKVDGLVVSATETASADDITTIRKAVGEEPIILFPGIGAQSGDMEKAIVHGGWNVLLNVGRSIAESPEPERAAAEYRKVLTESWIRVNAALEIIRTPGVYRYSPEKPFILSSGKESDYYVDIRALYSHPEPRSKIAELMLVKISMEGNVNVDKVATTETAGIPIASIVADRLCKGLVYVRHKEKGYGTGRKVEGIVQHGDRVICVDDLTTTGETAEDCVKAVSELGGKVLAYYVVFDREEGAADRLSSIGVRLSCLTNTSTLRSLMKKAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DTFY01000004
EMBL· GenBank· DDBJ
HGI27858.1
EMBL· GenBank· DDBJ
Genomic DNA
DRZT01000158
EMBL· GenBank· DDBJ
HHP52603.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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