A0A7J3MVC2 · A0A7J3MVC2_9ARCH

  • Protein
    Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
  • Gene
    flpA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

122720406080100120140160180200220
TypeIDPosition(s)Description
Binding site84-85S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site103-104S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site129-130S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site149-152S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentbox C/D methylation guide snoRNP complex
Molecular Functionhistone H2AQ104 methyltransferase activity
Molecular FunctionRNA binding
Molecular FunctionrRNA methyltransferase activity
Biological Processbox C/D sno(s)RNA 3'-end processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
  • EC number

Gene names

    • Name
      flpA
    • ORF names
      ENT71_00750
      , ENU65_05210

Organism names

Accessions

  • Primary accession
    A0A7J3MVC2

Subcellular Location

Interaction

Subunit

Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.

Family & Domains

Sequence similarities

Belongs to the methyltransferase superfamily. Fibrillarin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    25,960
  • Last updated
    2021-04-07 v1
  • Checksum
    857D8B55CD63FE73
MIEPHESFMGVYWIIEQSQRFLATKSLDPRTSVYGERLFRHGDAEYREWIPYRSKLAAAILTGLKELPIKPSVRVLYLGSATGTTVSHVSDIVGHTGIVFAVDFAPRVMAQFIERVARRRSNIIPILEDARLPERYRAFVGKVDVVYCDVAQPEQAKLLIDNCITYLKKGGEALLAVKARSIDSTEDPEKVFRREISILEKGGLRVKEHVRLEPYEEDHIMVRVKYD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DTDI01000129
EMBL· GenBank· DDBJ
HGT97487.1
EMBL· GenBank· DDBJ
Genomic DNA
DSZS01000023
EMBL· GenBank· DDBJ
HGU72445.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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