A0A7J3MVC2 · A0A7J3MVC2_9ARCH
- ProteinFibrillarin-like rRNA/tRNA 2'-O-methyltransferase
- GeneflpA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 84-85 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: TT | ||||||
Binding site | 103-104 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DF | ||||||
Binding site | 129-130 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DA | ||||||
Binding site | 149-152 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DVAQ |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | box C/D methylation guide snoRNP complex | |
Molecular Function | histone H2AQ104 methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | rRNA methyltransferase activity | |
Biological Process | box C/D sno(s)RNA 3'-end processing | |
Biological Process | tRNA processing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibrillarin-like rRNA/tRNA 2'-O-methyltransferase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Nitrososphaerota > Nitrososphaeria
Accessions
- Primary accessionA0A7J3MVC2
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
Structure
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)25,960
- Last updated2021-04-07 v1
- Checksum857D8B55CD63FE73