A0A7I8WY48 · A0A7I8WY48_BURXY
- ProteinPhosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids706 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 408 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 408-412 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNQIH | ||||||
Binding site | 412 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 448 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 449 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 449 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 449 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 566 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 566 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 617 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | regulation of signal transduction | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Aphelenchoidea > Aphelenchoididae > Bursaphelenchus
Accessions
- Primary accessionA0A7I8WY48
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MRPRHDRAGPSGVDSPTTTSRSATPTTKKHHHPFGG | ||||||
Region | 50-114 | Disordered | ||||
Sequence: RSRPSRHFSPPVNPSEPNTSQSYKQSPTLQRGDRHGMTGSSGRLPSSSSSGGFHQHLLGVGSGGP | ||||||
Compositional bias | 51-104 | Polar residues | ||||
Sequence: SRPSRHFSPPVNPSEPNTSQSYKQSPTLQRGDRHGMTGSSGRLPSSSSSGGFHQ | ||||||
Region | 132-154 | Disordered | ||||
Sequence: QPTSAGGCRPVSRASSVASQDPQ | ||||||
Compositional bias | 139-153 | Polar residues | ||||
Sequence: CRPVSRASSVASQDP | ||||||
Domain | 329-661 | PDEase | ||||
Sequence: APPEYGVECQKEIVVYMDRLGDWGINVFKINELSKGHALTSITYTILRERGLLKRFDIPATTLITYLLHLEHHYKDNPYHNQIHGADVTQSMHVLLSSTALEGVFTDQETLAAIFAAAIHDVDHPGYTNQYLINTNNELAIMYNDESVLEQHHLAVAFKLLQDVSCDFLVNWSKKQRQAFRKTVIGMVLATDMSKHMSLLADLKTMVESKKVAGNSVLQLDKYNDRIQVLQSMIHCADLSNPTKPIELYRNWNQRILEEYWKQGDKEKELGLEVSPMCDRYNVTIEKSQVGFIDYIVHPLFETWAELVHPHAQYILDQLEDNRQWYLSRIPDE | ||||||
Region | 658-706 | Disordered | ||||
Sequence: IPDEPATAREGDDEDQEEDEDRMTQPLSGQLEPIPSPDESIGDSVELNN |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length706
- Mass (Da)79,372
- Last updated2021-04-07 v1
- Checksum3E9F2ABF6F8490F8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 51-104 | Polar residues | ||||
Sequence: SRPSRHFSPPVNPSEPNTSQSYKQSPTLQRGDRHGMTGSSGRLPSSSSSGGFHQ | ||||||
Compositional bias | 139-153 | Polar residues | ||||
Sequence: CRPVSRASSVASQDP |
Keywords
- Technical term