A0A7I5E8U4 · A0A7I5E8U4_HAECO

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-14ITP (UniProtKB | ChEBI)
Binding site36Mg2+ (UniProtKB | ChEBI)
Binding site48ITP (UniProtKB | ChEBI)
Binding site64Mg2+ (UniProtKB | ChEBI)
Binding site64-65ITP (UniProtKB | ChEBI)
Binding site140-143ITP (UniProtKB | ChEBI)
Binding site163ITP (UniProtKB | ChEBI)
Binding site168-169ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Trichostrongylidae > Haemonchus

Accessions

  • Primary accession
    A0A7I5E8U4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    184
  • Mass (Da)
    20,597
  • Last updated
    2021-04-07 v1
  • Checksum
    9758DE83BFC8F1C9
MSRTITFVTGNAGKLAEVRAILSSFEVRAVDVDIDEYQGEPDYVAERKAKEAAERVEGPILVEDTSLCFNAFKGLPGVYIKWFLKKLGPSGLYQMLAGYDDKSAYAQCIFAYTEGKGQPVHIFRGRCPGHIVSPRGPPNFGWDPCFQPEGFTQTFAEMSSETKNKISHRAKALELVKKFFEDRK

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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