A0A7C5X2R8 · A0A7C5X2R8_9AQUI
- ProteintRNA (adenine(58)-N(1))-methyltransferase TrmI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids246 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the S-adenosyl-L-methionine-dependent formation of N1-methyladenine at position 58 (m1A58) in tRNA.
Catalytic activity
- adenosine58 in tRNA + S-adenosyl-L-methionine = N1-methyladenosine58 in tRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 101-104 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: SGAL | ||||||
Binding site | 119 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 147 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 164 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | tRNA (m1A) methyltransferase complex | |
Molecular Function | tRNA (adenine(58)-N1)-methyltransferase activity | |
Biological Process | tRNA methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (adenine(58)-N(1))-methyltransferase TrmI
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Aquificota > Aquificia > Aquificales > Aquificaceae > Thermocrinis
Accessions
- Primary accessionA0A7C5X2R8
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homotetramer composed of a dimer of dimers.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 54-231 | tRNA (adenine58-N1)-methyltransferase catalytic subunit TRM61 C-terminal | ||||
Sequence: LLKPNLEAIILYGFKRKTQIIYPKDAFYIAFKLGINKSSTVLEFGIGSGALTAVLSELAGKVVAYEVSQEFYENALKNWDTFGLCKNVEAINQDFMDADLSGREFDACFVDVREPWLYLKKVHSVLKNSAMCGFLLPTTNQVSRLLQEMDGLFAGVEVMEILLRKYKPVYERLRPEDI |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length246
- Mass (Da)28,265
- Last updated2020-12-02 v1
- ChecksumF7997D0F7A371856