A0A7C5SW07 · A0A7C5SW07_9AQUI

  • Protein
    ATP-dependent protease subunit HslV
  • Gene
    hslV
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent cleavage of peptide bonds with broad specificity.
    EC:3.4.25.2 (UniProtKB | ENZYME | Rhea)

Activity regulation

Allosterically activated by HslU binding.

Features

Showing features for active site, binding site.

117320406080100120140160
TypeIDPosition(s)Description
Active site2
Binding site157Na+ (UniProtKB | ChEBI)
Binding site160Na+ (UniProtKB | ChEBI)
Binding site163Na+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentHslUV protease complex
Cellular Componentproteasome core complex
Molecular Functionmetal ion binding
Molecular Functionthreonine-type endopeptidase activity
Biological Processproteolysis involved in protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent protease subunit HslV
  • EC number

Gene names

    • Name
      hslV
    • ORF names
      ENN04_01870

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SpSt-114
  • Taxonomic lineage
    Bacteria > Aquificota > Aquificia > Aquificales > Aquificaceae > Thermocrinis

Accessions

  • Primary accession
    A0A7C5SW07

Subcellular Location

Keywords

Interaction

Subunit

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.

Family & Domains

Sequence similarities

Belongs to the peptidase T1B family. HslV subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    18,665
  • Last updated
    2020-12-02 v1
  • Checksum
    3AC12251AB8A4BB1
MTTIIAVKRDGVVVMGGDGQVTLGASVLKHGAKKVRRIYNGSVLVGFAGAAADGLALMERLEGKLEEFRGNLLRASVELAKEWRTDRALRRLDAMLLCANLEHLLVISGTGDVMEPDEPIMAIGSGGDYARACALALYKHTNLSAEEIVKESLSIAAKICIYTNESFYLEKLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSAC01000024
EMBL· GenBank· DDBJ
HHO73367.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp