A0A7C5JB92 · A0A7C5JB92_9GAMM

Function

function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site242Zn2+ (UniProtKB | ChEBI)
Binding site305Zn2+ (UniProtKB | ChEBI)
Binding site306Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase

Gene names

    • ORF names
      ENK51_00135

Organism names

Accessions

  • Primary accession
    A0A7C5JB92

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-320Hcy-binding
Domain351-435Pterin-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    435
  • Mass (Da)
    47,407
  • Last updated
    2020-12-02 v1
  • Checksum
    FFFB588E40F5D675
MSKTLEQLLAERIVILDGAMGTMIQQHKLDEAGYRGERFADWPSDLKGNNDLLTLTQPQIIRGIHSEYLAAGADIVETNTFNANSISMADYAMESLVYEINVESARLAREACDAVATPDSPRFVAGVLGPTNRTASLSPDVNRPGFRNIDFDTLCESYLEAIKGLVDGGSDIILVETIFDTLNAKAALFAIEDYFETSGKKLPVMISGTITDASGRTLSGQTAEAFWNSLRHIEPISFGFNCALGADELRQYVEEVAGIANCHINSHPNAGLPNAFGEYDETPEQMAAEIEGWARSGFINIIGGCCGTTPAHIEAIAEAVGKYGPRKVPENDHLTRLSGLEPFNIGPDSLFVNVGERNNVTGSAKFKRLILEERFDEALEVSREQVENGAHIIDVNMDEAMLDGKQAMIDFLNLIASEPDIARVPVMVDSSKWEI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue435

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DRQN01000002
EMBL· GenBank· DDBJ
HHH47287.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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