A0A7C2DBQ1 · A0A7C2DBQ1_UNCAC
- Protein1,4-dihydroxy-2-naphthoyl-CoA synthase
- GenemenB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids270 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Catalytic activity
- 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
Cofactor
Pathway
Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.
Quinol/quinone metabolism; menaquinone biosynthesis.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: R | ||||||
Binding site | 70-74 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: SGGDQ | ||||||
Binding site | 82 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: Y | ||||||
Site | 82 | Important for catalysis | ||||
Sequence: Y | ||||||
Binding site | 114-118 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: YAIGG | ||||||
Binding site | 139-141 | hydrogencarbonate (UniProtKB | ChEBI) | ||||
Sequence: QTG | ||||||
Binding site | 140 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: T | ||||||
Binding site | 146 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: S | ||||||
Binding site | 243 | substrate; ligand shared between two neighboring subunits | ||||
Sequence: Y | ||||||
Site | 243 | Important for catalysis | ||||
Sequence: Y | ||||||
Binding site | 258 | substrate; ligand shared between two neighboring subunits | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity | |
Biological Process | menaquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1,4-dihydroxy-2-naphthoyl-CoA synthase
- EC number
- Short namesDHNA-CoA synthase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes
Accessions
- Primary accessionA0A7C2DBQ1
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)29,814
- Last updated2020-12-02 v1
- ChecksumCEDE95ACECEA1D17