A0A799GJM0 · A0A799GJM0_ECOLX

  • Protein
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • Gene
    ispC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site37NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site124NADPH (UniProtKB | ChEBI)
Binding site1251-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site126NADPH (UniProtKB | ChEBI)
Binding site150Mn2+ (UniProtKB | ChEBI)
Binding site1511-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1521-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site152Mn2+ (UniProtKB | ChEBI)
Binding site1861-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2091-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site215NADPH (UniProtKB | ChEBI)
Binding site2221-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2271-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2281-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2311-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site231Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      ispC
    • Synonyms
      dxr
    • ORF names
      A2J79_001328
      , A5U30_000300

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 93335
    • PNUSAE002719
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A799GJM0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-1321-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain146-2391-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain271-387DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    398
  • Mass (Da)
    43,404
  • Last updated
    2020-12-02 v1
  • Checksum
    D15D96E77EFBC6B7
MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQSACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AATCLQ010000006
EMBL· GenBank· DDBJ
EFJ6480991.1
EMBL· GenBank· DDBJ
Genomic DNA
AATLZG010000002
EMBL· GenBank· DDBJ
EFM8152737.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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