A0A702BMF1 · A0A702BMF1_SALBN

Function

function

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40L-tryptophan (UniProtKB | ChEBI)
Binding site291-293L-tryptophan (UniProtKB | ChEBI)
Binding site328-329chorismate (UniProtKB | ChEBI)
Binding site361Mg2+ (UniProtKB | ChEBI)
Binding site449chorismate (UniProtKB | ChEBI)
Binding site469chorismate (UniProtKB | ChEBI)
Binding site483-485chorismate (UniProtKB | ChEBI)
Binding site498Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionanthranilate synthase activity
Molecular Functionmetal ion binding
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate synthase component 1
  • EC number

Gene names

    • Name
      trpE
    • ORF names
      G0D16_08545

Organism names

Accessions

  • Primary accession
    A0A702BMF1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-191Anthranilate synthase component I N-terminal
Domain244-502Chorismate-utilising enzyme C-terminal

Sequence similarities

Belongs to the anthranilate synthase component I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    57,031
  • Last updated
    2020-12-02 v1
  • Checksum
    A13DDFE8E3AAEFD3
MQTSKPTLELLTCDAVYRENPTALFHQVCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSDNGAALLPLLDAVLPAGVENESLPAGRLLRFPPVSPLLDEDARLCSLSVFDAFRLLQSLVNVPAQEREAMFFGGLFAYDLVAGFEALPLLEAGNNCPDYCFYLAETLMVIDHQKKSTRIQASLFTANDGEKQRLNARLTHLSQQLTQPAPPLPVTPVPDMRCECNQSDDAFGVVVRQLQKAIRAGEIFQVVPSRRFSIPCPSPLAAYYVLKKSNPSPYMFFMQDESFTLFGASPESSLKYDATSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELDMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGQRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATVQAGAGIVLDSVAQSEADETRNKARAVLRAIATAHHAQETF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DAAMHO010000008
EMBL· GenBank· DDBJ
HAC6694335.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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