A0A6V8QXV1 · A0A6V8QXV1_9HYPO
- ProteinMultifunctional tryptophan biosynthesis protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids761 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
Catalytic activity
- 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 104 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 198 | |||||
Sequence: H | ||||||
Active site | 200 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | anthranilate synthase activity | |
Molecular Function | indole-3-glycerol-phosphate synthase activity | |
Molecular Function | phosphoribosylanthranilate isomerase activity | |
Biological Process | glutamine metabolic process | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional tryptophan biosynthesis protein
Including 3 domains:
- Recommended nameAnthranilate synthase component 2
- EC number
- Short namesAS
- Alternative names
- Recommended nameIndole-3-glycerol phosphate synthase
- EC number
- Short namesIGPS
- Recommended nameN-(5'-phosphoribosyl)anthranilate isomerase
- EC number
- Short namesPRAI
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Hypocreaceae > Trichoderma
Accessions
- Primary accessionA0A6V8QXV1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-215 | Glutamine amidotransferase | ||||
Sequence: LIDNYDSFTWNIYQYLVLEGATVHVYRNDKITVEELIKKNPTQLIISPGPGHPQTDSGVSRDAIRHFAGKIPVLGVCMGLQCMFDVYGGEVSSAGEWLHGKTSPLTHDAKGVFAGLPQGLPVTRYHSLAGTHLTLPERLEVTAWVAKPDGSAGIIQGVRHKDFVVEGVQFHPESILTAEGRVMIKNFL | ||||||
Domain | 250-512 | Indole-3-glycerol phosphate synthase | ||||
Sequence: LQNIYASRRIAVARQKEIPSQRMSDLQAAYDLNAAPPLVPFVSRLKQSPFDVSLMAEIKRGSPSKGVFALETQAPVQAHKYALAGASVISVLTEPEWFKGSIEDLRAVRQVLNGMPNRPAILRKEFIFEEYQILEARLAGADTVLLIVKMLEVELLERLYKYSQSLGMEPLVEVQNADEMTIAVKLGAKAIGVNNRNLETFEVDINTTGRLRSMVPDTTIICALSGINKHQDVLDCKRDGINAVLVGEAIMRAPDASVFISEL | ||||||
Domain | 574-755 | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) | ||||
Sequence: DAVHSATKSSVAPAKISIPSSSATDFFSLTANNLKTPRTQVVGIFQNQPLSEVLEKQRLYNLDLVQLHGEEPIEWAKAIPVPVIRCFKPGHPSLGIRGYHAVPLLDSGAGSGKLLDVSSVKEVLRKDPDLRIFLAGGLNPENVAEAVNALGEYSSQVIGVDVSSGVEEDGKQSLARITAFVN |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length761
- Mass (Da)82,324
- Last updated2020-12-02 v1
- ChecksumF6A59B2A96FF7356
Keywords
- Technical term