A0A6P8R5V5 · A0A6P8R5V5_GEOSA
- ProteinPleckstrin homology domain-containing family H member 2 isoform X4
- GenePLEKHH2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1083 (go to sequence)
- Protein existencePredicted
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Molecular Function | actin binding | |
Biological Process | negative regulation of actin filament depolymerization |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Gymnophiona > Geotrypetes
Accessions
- Primary accessionA0A6P8R5V5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 28-115 | |||||
Sequence: RVQASKIRELLAEKMQQLERQVLEANRRADKAHQQVQVMEEKLKEANIQTSESETRLYKRCQNLETLGQEKDDAIHNLEQELEKQKQM | ||||||
Region | 206-283 | Disordered | ||||
Sequence: PFMDDSSGSEEEDSSTSSSQTSESDCRNRSGTGSPRAMKRGASLSSMASESDYAIPPDAYSTDTEYSEPEQKLLKTCS | ||||||
Compositional bias | 217-236 | Polar residues | ||||
Sequence: EDSSTSSSQTSESDCRNRSG | ||||||
Compositional bias | 269-283 | Polar residues | ||||
Sequence: TEYSEPEQKLLKTCS | ||||||
Domain | 293-387 | PH | ||||
Sequence: VLEKSGYLLKMSGRVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASSQILRGDGKQTVQLMTEKRTFYLTADSPNLLEEWIRVLQSVLR | ||||||
Domain | 401-509 | PH | ||||
Sequence: RPLMKGLLTKVKHGYSKRVWCALVGKTLYYFRSHEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASSRSLLSTHYTIAVHPKEQGPTYLLIGSKHEKDTWLYHLTIAAG | ||||||
Domain | 545-700 | MyTH4 | ||||
Sequence: HTKEGLKSPLTTLPSEALQTEALKLFKTCQLFINAAVDSPAIDYHVSLAQSALQVCLTHPELQNEIYCQLIKQTRRRQAQKPSGPVQAWQLLALCVGLFLPQHPFLWLLKLHLKRSTDLRTETGKYAVYCQRCVERTQHNGDREARPSRMEILSIL | ||||||
Domain | 711-1041 | FERM | ||||
Sequence: FSIPVHFLNGTYQVVGFDASTTVEEFLRTLNQDVGMRRPGQSGFALFTDDPSGKDLEYCLQRSIKICDIISKWEQAFKQQHPGKCESTRTVRLTYKNRLCFSKQFSGETEREKLLLMFQTNDQIVHGLFPVNKELALEMAALVAQVETGDYERPFSTSAGQGTSQSKGDQAVKQALERFYPKQYRHGCSEEQLRQLHHRLSAKWMALCGHSATDCMRIYLTVARKWPFYGAKLFSAKPLPPSPIENTFIWLAVHEDGISILEYSSLCAVITYLHKSLMTFGGYRDDFMLVFSSCHTKEKPNEKLLFTMAKPKVLEITLLIASYINAFHQQK | ||||||
Region | 1064-1083 | Disordered | ||||
Sequence: QMGSQPLLANNRPTKGPTLL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,083
- Mass (Da)122,617
- Last updated2020-12-02 v1
- ChecksumD8BB455A2DCBE222
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6P8QHW8 | A0A6P8QHW8_GEOSA | PLEKHH2 | 1439 | ||
A0A6P8Q731 | A0A6P8Q731_GEOSA | PLEKHH2 | 1389 | ||
A0A6P8QFU4 | A0A6P8QFU4_GEOSA | PLEKHH2 | 1438 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 217-236 | Polar residues | ||||
Sequence: EDSSTSSSQTSESDCRNRSG | ||||||
Compositional bias | 269-283 | Polar residues | ||||
Sequence: TEYSEPEQKLLKTCS |
Keywords
- Technical term