A0A6P5CKC6 · A0A6P5CKC6_BOSIN

  • Protein
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • Gene
    NTMT1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site69S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site74S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site91-93S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site119-120S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site135S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionN-terminal protein N-methyltransferase activity
Biological ProcessN-terminal peptidyl-alanine methylation
Biological ProcessN-terminal peptidyl-proline methylation
Biological ProcessN-terminal peptidyl-serine methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • EC number
  • Alternative names
    • Alpha N-terminal protein methyltransferase 1A
    • Methyltransferase-like protein 11A
    • X-Pro-Lys N-terminal protein methyltransferase 1A

Gene names

    • Name
      NTMT1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A6P5CKC6

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the methyltransferase superfamily. NTM1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    223
  • Mass (Da)
    25,258
  • Last updated
    2020-12-02 v1
  • Checksum
    F38506062CC42BCC
MTSEVIEDEKQFYSKAKTYWKEVPATVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSYALDCGAGIGRITKRLLLPLFGVVDMVDVTEDFLVKAKTYLGEEGKRVRNFFCCGLQDFSPEPQSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRALDVVHRIVRSAGLSLLAQERQENLPDEIYHVYSLALR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6P5CNT5A0A6P5CNT5_BOSINNTMT1135

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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