A0A6P4Z3Z1 · A0A6P4Z3Z1_BRABE

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Features

Showing features for active site, binding site.

1761100200300400500600700
TypeIDPosition(s)Description
Active site393Proton donor
Binding site393-397AMP (UniProtKB | ChEBI)
Binding site397Zn2+ 1 (UniProtKB | ChEBI)
Binding site433Zn2+ 1 (UniProtKB | ChEBI)
Binding site434AMP (UniProtKB | ChEBI)
Binding site434Zn2+ 2 (UniProtKB | ChEBI)
Binding site434Zn2+ 1 (UniProtKB | ChEBI)
Binding site551AMP (UniProtKB | ChEBI)
Binding site551Zn2+ 1 (UniProtKB | ChEBI)
Binding site602AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological ProcesscAMP catabolic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      LOC109475178

Organism names

Accessions

  • Primary accession
    A0A6P4Z3Z1

Proteomes

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-28Polar residues
Region1-41Disordered
Region62-117Disordered
Compositional bias67-117Polar residues
Region149-178Disordered
Region253-278Disordered
Compositional bias255-270Basic and acidic residues
Domain314-646PDEase
Region641-761Disordered
Compositional bias658-676Basic and acidic residues
Compositional bias677-693Acidic residues
Compositional bias737-761Basic and acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    761
  • Mass (Da)
    85,892
  • Last updated
    2020-12-02 v1
  • Checksum
    A652C3D04235B9FB
MSLRHCSFSTPSFSRFSRSRNSFDVENGPPPSRSPLEAASPSSGLILQANFPQRRESFLYRSDSEFELSPKSMSRNSSIASETSQQQQQQQQCQQQQCQQPQPNKLPSSRRSSIASSVHESDLIVTPFAQVLASLRSVRNNFISLTNVPASSSRRSSVGSQSHPSQGTSSSSNNKLTVPDENQSRLAMETLEELDWCLDQLESIQTHRSVSEMASSKFKRMLNRELSHFKETSKSGNQVSEFICNTFLDKQQEIDLPSPTEKDSPEESKPPGRTKGPLSHVSALLIMPESVTNFESGLRKLRHANSFTGIVPRFGVEVSADREDDLAKEMDMSKWGVDCFKIDTLTNGRALTAVTYTILQERDLIKTFKIPANTLITYLMTLEDHYHREVPYHNNRHAADVTQTTHYLLGMQALENVFTDLEILASIFASAIHDVDHPGVNNQFLIVTSSELAILYNDESCLENHHLAVAFKLLQEENCDIFCNLSKKQRSTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLQNMVHCADLGNPTKPLELYRQWLDKLMDEFYHQGDRERNKQLEISAMCDRHNASVEKSQVGFIDFIVHPLWETWADLVHPDAQSILDQLEENRDWFASQIPMSPSPGPDSKEKNGSQDSPSHKEQFRFDMTPELDEEDNLDDDDDDEDSATPVNPSTPTPRSQEIRIESRIRGQPRMGSEDRGQPCMLPQGSEDSESESDHSHMIPFAREDSADIESD

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6P4Z3X3A0A6P4Z3X3_BRABELOC109475178929
A0A6P4ZJM5A0A6P4ZJM5_BRABELOC109475178780
A0A6P4ZJM9A0A6P4ZJM9_BRABELOC109475178763
A0A6P4ZJL7A0A6P4ZJL7_BRABELOC109475178901
A0A6P4ZJM1A0A6P4ZJM1_BRABELOC109475178869
A0A6P4ZNQ7A0A6P4ZNQ7_BRABELOC109475178915
A0A6P4ZNR0A0A6P4ZNR0_BRABELOC109475178869
A0A6P4ZNR3A0A6P4ZNR3_BRABELOC109475178828
A0A6P4ZNR8A0A6P4ZNR8_BRABELOC109475178764
A0A6P4ZBL4A0A6P4ZBL4_BRABELOC109475178897
A0A6P4ZBL9A0A6P4ZBL9_BRABELOC109475178841
A0A6P4ZBM3A0A6P4ZBM3_BRABELOC109475178771
A0A6P4YP80A0A6P4YP80_BRABELOC109475178893
A0A6P4YP84A0A6P4YP84_BRABELOC109475178833
A0A6P4YP94A0A6P4YP94_BRABELOC109475178879
A0A6P4YP75A0A6P4YP75_BRABELOC109475178921
A0A6P4ZBN0A0A6P4ZBN0_BRABELOC109475178758
A0A6P4Z3X8A0A6P4Z3X8_BRABELOC109475178901
A0A6P4Z3Y3A0A6P4Z3Y3_BRABELOC109475178846
A0A6P4Z3Y6A0A6P4Z3Y6_BRABELOC109475178745

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-28Polar residues
Compositional bias67-117Polar residues
Compositional bias255-270Basic and acidic residues
Compositional bias658-676Basic and acidic residues
Compositional bias677-693Acidic residues
Compositional bias737-761Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp