A0A6P4Z3Z1 · A0A6P4Z3Z1_BRABE
- ProteinPhosphodiesterase
- GeneLOC109475178
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids761 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 393 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 393-397 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNNRH | ||||||
Binding site | 397 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 433 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 434 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 434 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 434 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 551 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 551 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 602 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | cAMP catabolic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionA0A6P4Z3Z1
Proteomes
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-28 | Polar residues | ||||
Sequence: MSLRHCSFSTPSFSRFSRSRNSFDVENG | ||||||
Region | 1-41 | Disordered | ||||
Sequence: MSLRHCSFSTPSFSRFSRSRNSFDVENGPPPSRSPLEAASP | ||||||
Region | 62-117 | Disordered | ||||
Sequence: SDSEFELSPKSMSRNSSIASETSQQQQQQQQCQQQQCQQPQPNKLPSSRRSSIASS | ||||||
Compositional bias | 67-117 | Polar residues | ||||
Sequence: ELSPKSMSRNSSIASETSQQQQQQQQCQQQQCQQPQPNKLPSSRRSSIASS | ||||||
Region | 149-178 | Disordered | ||||
Sequence: PASSSRRSSVGSQSHPSQGTSSSSNNKLTV | ||||||
Region | 253-278 | Disordered | ||||
Sequence: EIDLPSPTEKDSPEESKPPGRTKGPL | ||||||
Compositional bias | 255-270 | Basic and acidic residues | ||||
Sequence: DLPSPTEKDSPEESKP | ||||||
Domain | 314-646 | PDEase | ||||
Sequence: FGVEVSADREDDLAKEMDMSKWGVDCFKIDTLTNGRALTAVTYTILQERDLIKTFKIPANTLITYLMTLEDHYHREVPYHNNRHAADVTQTTHYLLGMQALENVFTDLEILASIFASAIHDVDHPGVNNQFLIVTSSELAILYNDESCLENHHLAVAFKLLQEENCDIFCNLSKKQRSTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLQNMVHCADLGNPTKPLELYRQWLDKLMDEFYHQGDRERNKQLEISAMCDRHNASVEKSQVGFIDFIVHPLWETWADLVHPDAQSILDQLEENRDWFASQIPMS | ||||||
Region | 641-761 | Disordered | ||||
Sequence: SQIPMSPSPGPDSKEKNGSQDSPSHKEQFRFDMTPELDEEDNLDDDDDDEDSATPVNPSTPTPRSQEIRIESRIRGQPRMGSEDRGQPCMLPQGSEDSESESDHSHMIPFAREDSADIESD | ||||||
Compositional bias | 658-676 | Basic and acidic residues | ||||
Sequence: GSQDSPSHKEQFRFDMTPE | ||||||
Compositional bias | 677-693 | Acidic residues | ||||
Sequence: LDEEDNLDDDDDDEDSA | ||||||
Compositional bias | 737-761 | Basic and acidic residues | ||||
Sequence: DSESESDHSHMIPFAREDSADIESD |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length761
- Mass (Da)85,892
- Last updated2020-12-02 v1
- ChecksumA652C3D04235B9FB
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6P4Z3X3 | A0A6P4Z3X3_BRABE | LOC109475178 | 929 | ||
A0A6P4ZJM5 | A0A6P4ZJM5_BRABE | LOC109475178 | 780 | ||
A0A6P4ZJM9 | A0A6P4ZJM9_BRABE | LOC109475178 | 763 | ||
A0A6P4ZJL7 | A0A6P4ZJL7_BRABE | LOC109475178 | 901 | ||
A0A6P4ZJM1 | A0A6P4ZJM1_BRABE | LOC109475178 | 869 | ||
A0A6P4ZNQ7 | A0A6P4ZNQ7_BRABE | LOC109475178 | 915 | ||
A0A6P4ZNR0 | A0A6P4ZNR0_BRABE | LOC109475178 | 869 | ||
A0A6P4ZNR3 | A0A6P4ZNR3_BRABE | LOC109475178 | 828 | ||
A0A6P4ZNR8 | A0A6P4ZNR8_BRABE | LOC109475178 | 764 | ||
A0A6P4ZBL4 | A0A6P4ZBL4_BRABE | LOC109475178 | 897 | ||
A0A6P4ZBL9 | A0A6P4ZBL9_BRABE | LOC109475178 | 841 | ||
A0A6P4ZBM3 | A0A6P4ZBM3_BRABE | LOC109475178 | 771 | ||
A0A6P4YP80 | A0A6P4YP80_BRABE | LOC109475178 | 893 | ||
A0A6P4YP84 | A0A6P4YP84_BRABE | LOC109475178 | 833 | ||
A0A6P4YP94 | A0A6P4YP94_BRABE | LOC109475178 | 879 | ||
A0A6P4YP75 | A0A6P4YP75_BRABE | LOC109475178 | 921 | ||
A0A6P4ZBN0 | A0A6P4ZBN0_BRABE | LOC109475178 | 758 | ||
A0A6P4Z3X8 | A0A6P4Z3X8_BRABE | LOC109475178 | 901 | ||
A0A6P4Z3Y3 | A0A6P4Z3Y3_BRABE | LOC109475178 | 846 | ||
A0A6P4Z3Y6 | A0A6P4Z3Y6_BRABE | LOC109475178 | 745 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-28 | Polar residues | ||||
Sequence: MSLRHCSFSTPSFSRFSRSRNSFDVENG | ||||||
Compositional bias | 67-117 | Polar residues | ||||
Sequence: ELSPKSMSRNSSIASETSQQQQQQQQCQQQQCQQPQPNKLPSSRRSSIASS | ||||||
Compositional bias | 255-270 | Basic and acidic residues | ||||
Sequence: DLPSPTEKDSPEESKP | ||||||
Compositional bias | 658-676 | Basic and acidic residues | ||||
Sequence: GSQDSPSHKEQFRFDMTPE | ||||||
Compositional bias | 677-693 | Acidic residues | ||||
Sequence: LDEEDNLDDDDDDEDSA | ||||||
Compositional bias | 737-761 | Basic and acidic residues | ||||
Sequence: DSESESDHSHMIPFAREDSADIESD |
Keywords
- Technical term