A0A6J3Q7U8 · A0A6J3Q7U8_TURTR
- ProteinS-adenosylmethionine synthase
- GeneMAT1A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids332 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Catalytic activity
- ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Note: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
Pathway
Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine adenosyltransferase activity | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine synthase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Delphinidae > Tursiops
Accessions
- Primary accessionA0A6J3Q7U8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-52 | S-adenosylmethionine synthetase N-terminal | ||||
Sequence: MVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP | ||||||
Domain | 67-187 | S-adenosylmethionine synthetase central | ||||
Sequence: VGAGDQGLMFGYATDETEECMPLTIILAHRLNARMAELRRSGQLPWLRPDSKTQVTVQYTQECGAVIPVRIHTIVISVQHNEDVTLEDMRRALKEQVIRAVVPAQYLDKDTIYHLQPSGRF | ||||||
Domain | 189-325 | S-adenosylmethionine synthetase C-terminal | ||||
Sequence: IGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWE |
Sequence similarities
Belongs to the AdoMet synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)36,981
- Last updated2020-10-07 v1
- ChecksumA613C08C88EE4F17
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6J3Q7U2 | A0A6J3Q7U2_TURTR | MAT1A | 396 |
Keywords
- Technical term