A0A6J3GRI8 · A0A6J3GRI8_SAPAP
- ProteinInvolucrin
- GeneIVL
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids355 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | keratinization |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameInvolucrin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Cebinae > Sapajus
Accessions
- Primary accessionA0A6J3GRI8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Post-translational modification
Substrate of transglutaminase.
Interaction
Subunit
Directly or indirectly cross-linked to cornifelin (CNFN).
Structure
Family & Domains
Features
Showing features for compositional bias, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSQQHTLPVTLPPALSQELLNTVPPPINTQQEQRE | ||||||
Domain | 1-69 | Involucrin N-terminal | ||||
Sequence: MSQQHTLPVTLPPALSQELLNTVPPPINTQQEQREQPAPLPPPCQKVPVELPVEGSSKHEEKHVAIVKG | ||||||
Region | 1-128 | Disordered | ||||
Sequence: MSQQHTLPVTLPPALSQELLNTVPPPINTQQEQREQPAPLPPPCQKVPVELPVEGSSKHEEKHVAIVKGVPEHECEQQQQAQGQERQQQHWGQDKEHQKAGNPEQQLKQEEAQRETQQLQGQLEEEKK | ||||||
Compositional bias | 53-70 | Basic and acidic residues | ||||
Sequence: VEGSSKHEEKHVAIVKGV | ||||||
Compositional bias | 89-111 | Basic and acidic residues | ||||
Sequence: QHWGQDKEHQKAGNPEQQLKQEE | ||||||
Compositional bias | 149-283 | Basic and acidic residues | ||||
Sequence: KKQLLEFPEQQEGQLKHLEQQEKPLELPEQQEGQLKHLEEQKGQLKHLEHQEGQLELPEQVDQPKHLEQLEKQLEHPEQQEGQLKQQEEEQEQLKHLEQQEEQLKHLEQQEGHLEHLEQQEGELKHLEQCKGQLE | ||||||
Region | 149-336 | Disordered | ||||
Sequence: KKQLLEFPEQQEGQLKHLEQQEKPLELPEQQEGQLKHLEEQKGQLKHLEHQEGQLELPEQVDQPKHLEQLEKQLEHPEQQEGQLKQQEEEQEQLKHLEQQEEQLKHLEQQEGHLEHLEQQEGELKHLEQCKGQLEHLEQQEGQLELPEQQEGQLKDLEQQERQLEQPVFAPAPGQAQDIQQALPSKSE |
Sequence similarities
Belongs to the involucrin family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length355
- Mass (Da)41,500
- Last updated2020-10-07 v1
- ChecksumC281A893E7AFB757
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6J3GT35 | A0A6J3GT35_SAPAP | IVL | 418 | ||
A0A6J3GTS1 | A0A6J3GTS1_SAPAP | IVL | 379 | ||
A0A6J3GSM5 | A0A6J3GSM5_SAPAP | IVL | 399 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSQQHTLPVTLPPALSQELLNTVPPPINTQQEQRE | ||||||
Compositional bias | 53-70 | Basic and acidic residues | ||||
Sequence: VEGSSKHEEKHVAIVKGV | ||||||
Compositional bias | 89-111 | Basic and acidic residues | ||||
Sequence: QHWGQDKEHQKAGNPEQQLKQEE | ||||||
Compositional bias | 149-283 | Basic and acidic residues | ||||
Sequence: KKQLLEFPEQQEGQLKHLEQQEKPLELPEQQEGQLKHLEEQKGQLKHLEHQEGQLELPEQVDQPKHLEQLEKQLEHPEQQEGQLKQQEEEQEQLKHLEQQEEQLKHLEQQEGHLEHLEQQEGELKHLEQCKGQLE |
Keywords
- Technical term