A0A6B3LI67 · A0A6B3LI67_9BACT

  • Protein
    Aspartate 1-decarboxylase
  • Gene
    panD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyruvate (UniProtKB | Rhea| CHEBI:15361 )

Note: Binds 1 pyruvoyl group covalently per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site25Schiff-base intermediate with substrate; via pyruvic acid
Binding site57substrate
Active site58Proton donor
Binding site73-75substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaspartate 1-decarboxylase activity
Biological Processalanine biosynthetic process
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      panD
    • ORF names
      GXP69_01265

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BT327
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Hymenobacteraceae > Pontibacter

Accessions

  • Primary accession
    A0A6B3LI67

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_50257414031-24Aspartate 1-decarboxylase beta chain
Modified residue25Pyruvic acid (Ser)
ChainPRO_502574140425-115Aspartate 1-decarboxylase alpha chain

Post-translational modification

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

Keywords

Interaction

Subunit

Heterooctamer of four alpha and four beta subunits.

Family & Domains

Sequence similarities

Belongs to the PanD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    12,783
  • Last updated
    2020-06-17 v1
  • Checksum
    49F397DD5749707B
MYIEVLKSKIHRCKVTQAELHYVGSITIDEDLMDAANVVENEKVTIVNINNGERFETYVIKGERGTGTVCLNGPAARKVQVGDIVIVISYCSIPFAEAKAHKPTLVFPDQHNRLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAGWD010000001
EMBL· GenBank· DDBJ
NEM96309.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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