A0A6A6JUY5 · A0A6A6JUY5_WESOR

  • Protein
    DNA-(apurinic or apyrimidinic site) endonuclease 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

159450100150200250300350400450500550
TypeIDPosition(s)Description
Binding site8Mg2+ 1 (UniProtKB | ChEBI)
Binding site43Mg2+ 1 (UniProtKB | ChEBI)
Active site156
Active site195Proton donor/acceptor
Binding site195Mg2+ 1 (UniProtKB | ChEBI)
Binding site197Mg2+ 1 (UniProtKB | ChEBI)
Site197Transition state stabilizer
Site287Important for catalytic activity
Binding site312Mg2+ 1 (UniProtKB | ChEBI)
Active site313Proton acceptor
Binding site313Mg2+ 1 (UniProtKB | ChEBI)
Site313Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene names

    • ORF names
      EI97DRAFT_430609

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 379.55
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Sporormiaceae > Westerdykella

Accessions

  • Primary accession
    A0A6A6JUY5

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region380-471Disordered
Compositional bias385-407Polar residues
Compositional bias453-467Polar residues
Domain538-590GRF-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    66,087
  • Last updated
    2020-06-17 v1
  • Checksum
    ABC39EAE6C967EB1
MVRITTWNVNGIRNPFGYQPWRETRSFSAMFDILEADIVILQELKIQRKDLTDDMVLVPGWDCFFSLPKYKKGYSGVAIYTRQSVCAPIRAEEGLLGVLCPPGSSVPYRELPEQSCIGGYPNITQLTDLGVDPLSLDAEGRCVVVEFPAFVVVGVYSPANSSGTRDDFSFGFRCALDSRIRNLARLGKNVILAGDLNVSREEIDSARAEESMREEGETVEQYLNRPTRRLFNQLVENGKVPGQRDEGRETPILWDICREFHPAREGMYTHWEQKINARPGNFGSRIDYVLCSIDIKDWFCDANIQEGLMGSDHCPVYASIKEIVKWRGEQVHILDILNPPGMFKDGKRLRDYDTTVDILASSGKRLPEFTKRRSIKDMFASKSNPMVPTMATPAVTSQGSAQLSETRRTGEEGALGAQEAESPSAAVSPIKASQKRRLASGSPVKPVKRSKSNARESSPSQPPIKGGQQSLRGFFISKPTRVISDSEQPPMNGFNSTVPADVPTAEPADFAETKSGTDSKATQQTWSKLFSKKPLPRCEHGEPCTIYTVKKAGPNCGRQFFLCSRPLGPSGQKERGTEWRCPTYIWASDWKNSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias385-407Polar residues
Compositional bias453-467Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ML986486
EMBL· GenBank· DDBJ
KAF2279556.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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