A0A6A6JUY5 · A0A6A6JUY5_WESOR
- ProteinDNA-(apurinic or apyrimidinic site) endonuclease 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids594 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 8 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 43 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 156 | |||||
Sequence: Y | ||||||
Active site | 195 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 195 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 197 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 197 | Transition state stabilizer | ||||
Sequence: N | ||||||
Site | 287 | Important for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 312 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 313 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 313 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 313 | Interaction with DNA substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | endonuclease activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA repair |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDNA-(apurinic or apyrimidinic site) endonuclease 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Sporormiaceae > Westerdykella
Accessions
- Primary accessionA0A6A6JUY5
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 380-471 | Disordered | ||||
Sequence: ASKSNPMVPTMATPAVTSQGSAQLSETRRTGEEGALGAQEAESPSAAVSPIKASQKRRLASGSPVKPVKRSKSNARESSPSQPPIKGGQQSL | ||||||
Compositional bias | 385-407 | Polar residues | ||||
Sequence: PMVPTMATPAVTSQGSAQLSETR | ||||||
Compositional bias | 453-467 | Polar residues | ||||
Sequence: NARESSPSQPPIKGG | ||||||
Domain | 538-590 | GRF-type | ||||
Sequence: CEHGEPCTIYTVKKAGPNCGRQFFLCSRPLGPSGQKERGTEWRCPTYIWASDW |
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length594
- Mass (Da)66,087
- Last updated2020-06-17 v1
- ChecksumABC39EAE6C967EB1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 385-407 | Polar residues | ||||
Sequence: PMVPTMATPAVTSQGSAQLSETR | ||||||
Compositional bias | 453-467 | Polar residues | ||||
Sequence: NARESSPSQPPIKGG |
Keywords
- Technical term