A0A671NMC6 · A0A671NMC6_9TELE
- ProteinP2X purinoceptor
- Genep2rx4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids384 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Receptor for ATP that acts as a ligand-gated ion channel.
Catalytic activity
- Ca2+(in) = Ca2+(out)
- K+(in) = K+(out)
- Na+(in) = Na+(out)
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Cellular Component | plasma membrane | |
Cellular Component | postsynapse | |
Molecular Function | ATP binding | |
Molecular Function | extracellularly ATP-gated monoatomic cation channel activity | |
Molecular Function | purinergic nucleotide receptor activity | |
Biological Process | response to ATP |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameP2X purinoceptor
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Sinocyclocheilus
Accessions
- Primary accessionA0A671NMC6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 340-362 | Helical | ||||
Sequence: IGAGLALLGLVNVICDWIVLTIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 117↔166 | |||||
Sequence: CAENPTPASICTSHRDCKRGFNDARGDGVQTGRCVNYNDTVKTCEVLSWC | ||||||
Disulfide bond | 127↔150 | |||||
Sequence: CTSHRDCKRGFNDARGDGVQTGRC | ||||||
Disulfide bond | 133↔160 | |||||
Sequence: CKRGFNDARGDGVQTGRCVNYNDTVKTC | ||||||
Glycosylation | 185 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 218↔228 | |||||
Sequence: CVFSRKTDPDC | ||||||
Disulfide bond | 262↔271 | |||||
Sequence: CDLDMPQSWC |
Keywords
- PTM
PTM databases
Interaction
Subunit
Functional P2XRs are organized as homomeric and heteromeric trimers.
Structure
Sequence
- Sequence statusComplete
- Length384
- Mass (Da)43,645
- Last updated2020-06-17 v1
- Checksum9F129CC87B441BC2
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A671NIZ8 | A0A671NIZ8_9TELE | p2rx4 | 399 | ||
A0A671NR68 | A0A671NR68_9TELE | p2rx4 | 391 | ||
A0A671NM71 | A0A671NM71_9TELE | p2rx4 | 370 | ||
A0A671NMI7 | A0A671NMI7_9TELE | p2rx4 | 378 | ||
A0A671NKA7 | A0A671NKA7_9TELE | p2rx4 | 367 | ||
A0A671NKM4 | A0A671NKM4_9TELE | p2rx4 | 367 | ||
A0A671NHZ3 | A0A671NHZ3_9TELE | p2rx4 | 388 | ||
A0A671NIL4 | A0A671NIL4_9TELE | p2rx4 | 368 |
Keywords
- Technical term