A0A650CK75 · A0A650CK75_SULOH

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

129820406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site155Mn2+ (UniProtKB | ChEBI)
Binding site221Mn2+ (UniProtKB | ChEBI)
Binding site236Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processdefense response to virus
Biological Processmaintenance of CRISPR repeat elements

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR-associated endonuclease Cas1
  • EC number

Gene names

    • Name
      cas1
    • ORF names
      D1869_14630
      , HNQ62_002637

Organism names

  • Taxonomic identifier
  • Strains
    • TA-1
    • DSM 12421
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfurisphaera

Accessions

  • Primary accession
    A0A650CK75

Proteomes

Interaction

Subunit

Homodimer, forms a heterotetramer with a Cas2 homodimer.

Family & Domains

Sequence similarities

Belongs to the CRISPR-associated endonuclease Cas1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    34,459
  • Last updated
    2020-04-22 v1
  • Checksum
    1599EEB19662CCB9
MEKRIAFVKDWGAYIRVNKGRIECVVKNEVKWSLSPAEVSSIIFLVNSSLSTEVIRLANEFGIELVFFHDSEPIARVITAKYGGSMKVWIKQIREAKNNPEKYAKQFIYGKIHNQWVTIHYYEKKYGFKLGGDELYGITKEVITANNIEEIMVKEAEGAKIYWKGVKYLLPKELGFKGRKKKGENLDPFNKALNIGYGLLRKSVWGAVISAGLNPYIGFLHKFRSGRLSLVFDLMEEFRSPFVDRPLIGLARENYEKLKDLKVVYSTFVFDEDEIYTQARRLVNSILHGDEYRPFMAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHFY010000028
EMBL· GenBank· DDBJ
MBB5254863.1
EMBL· GenBank· DDBJ
Genomic DNA
CP045484
EMBL· GenBank· DDBJ
QGR18284.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp