A0A640W3M1 · A0A640W3M1_UNCTM

  • Protein
    tRNA-t(6)A37 methylthiotransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t6A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) at position 37 in tRNAs that read codons beginning with adenine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular FunctionN6-threonylcarbomyladenosine methylthiotransferase activity
Molecular FunctiontRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-t(6)A37 methylthiotransferase
  • EC number

Gene names

    • ORF names
      FE045_03005

Organism names

Accessions

  • Primary accession
    A0A640W3M1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-111MTTase N-terminal
Domain122-351Radical SAM core
Domain354-412TRAM

Sequence similarities

Belongs to the methylthiotransferase family. CDKAL1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    46,976
  • Last updated
    2020-04-22 v1
  • Checksum
    7C0C7907EDE41EB1
MKVYIETYGCAAAQGDAAIMEGILLQRGYEIVGEPEKADFVVIVTCIVVDTTQQRMISRIKKFKEMGKKIVVAECMASALPDLVKKLDENAILLPPRYIHHIADAIEGKRDFIEKPKVGLPRKIGIRLNIPIAEGCIYNCSYCITKLARGRLTSFPLEGLVKDAENAIKKGCKELRLTTQDTASYGIDIGKSLPELINEIASIEGEFRIRIGMMHPLSAYRIFDELMEAYENEKVYKFIHLPLQSASDKILRAMRRGYTYDLFKEMVDEFRKRFRHSTFATDIIVAFPGEGEEEFEETMKAMKELRPDITNVTRFSPRPFTEAAKLKKLPTQVAKQRSRAASELALKISYERNRELVGKTFRALLLEERNGWIVGKTDGYRSVYVKNAAIGEFVKVAIKKAKLTHLEGEITPQH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VBQR01000044
EMBL· GenBank· DDBJ
KAA0006484.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp