A0A5E4MT37 · A0A5E4MT37_9HEMI

  • Protein
    Protein kibra
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcytoplasm
Molecular Functionkinase binding
Molecular Functionmolecular adaptor activity
Biological Processcell migration
Biological Processnegative regulation of organ growth
Biological Processregulation of DNA-templated transcription
Biological Processregulation of hippo signaling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein kibra

Gene names

    • ORF names
      CINCED_3A011339

Organism names

  • Taxonomic identifier
  • Organism
    Cinara cedri
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Lachninae > Cinara

Accessions

  • Primary accession
    A0A5E4MT37

Proteomes

Subcellular Location

Interaction

Subunit

Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain9-42WW
Domain56-89WW
Region262-287Disordered
Coiled coil302-336
Coiled coil361-430
Region435-454Disordered
Region495-538Disordered
Compositional bias499-527Polar residues
Domain564-690C2
Region752-776Disordered
Compositional bias753-776Acidic residues
Compositional bias788-809Basic and acidic residues
Region788-822Disordered

Sequence similarities

Belongs to the WWC family. KIBRA subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,062
  • Mass (Da)
    119,369
  • Last updated
    2019-11-13 v1
  • Checksum
    31278A9995A1B00F
MPRRRNGEIPLPDGWDFARDYDGKVYFIDHNTKKTTWIDPRDRYTKPQSFADCIGNELPLGWEEAIDPVIGVYYINHFNQCTQLEDPRLEWRAIQEAMLRDYLHTAQDVLEAKKEIYDVKQQRLYLAQDEFNHLNNALTTLNTSRTSLCSSSSNISTKYDPDLLKSDVAHARERVTRLKRELEQIGVEMSCTRRGVETLSNVEQKLSTDGSRYNIVQAQAIVNELREIQQSLSSGQRERTGLMHSLAKLKDDLTRLQLCSATDDPDLQNHSSSTQLSDKLSTASQTDLSGELMPMGTRLAEMARMRLEYDEARKRIQNIQQQLADLEEKVMPGQEESDKDRLLLFQEKEQLLRELRSITPRSRSHREMTDIQGEIKKLEQDLNNALEMSNRAITDRLRLHEEKQLLLQQLKEALRSMTLLESQLKTLSASTLSVSSSSSLGSLSTTSSKGSLSSGLSFTDIYGGPQCLAPATYDRPVDMADLHKRVERLLRDDSQPPAYETMGESSNTVSNVTGVPYSRSCRPTSPPLSPISETPPRSVSAAVSDESVAGDSGVFEASHKSNFSTETSQVQIRLRYSIAEQVLHVCIERLRNVVALSIAESWQLFVKISLLPSGSNSSLSGCTKPISDLAKPRFGDSFAFNLPSNKLCTKTLQVNVWGLGPEDITECLACAQVSLAEFNETENNSWCKWYNLLSLKFMHNGSSLPSILLKDDGGGSDDSTIISSQTSTLTRNQGCCEENDAKFINVDNLNENGVEYEDGDSDDSVSDDDDEEEDDDDIEVYQLVNEKKELEQVLESPDKENDTEDKETNTEGAFSGSNGENNRVPTIVIKRSQTFSPTAKNQYICKLNRSDSDSAMNLYRRHISSSASMKGIGGSNADLAFRRNCLERRSLRVGRGPGTSPSRCMPNVNSTSWCRPPRTSIDLELDRQAQHARLLSLNDEISRLRQLKNTLEIAKETGDTDVAAWVLEDEEFQNLVKEAGDKTLDEKKVERRLKRASQKLYNLRKSKAGQGKPDIISFKEKMAFFTRPGVSVPVPPTKSSQDQKTTETRYQYTVDRVYGVEV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5E4MRH6A0A5E4MRH6_9HEMICINCED_3A011339990

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias499-527Polar residues
Compositional bias753-776Acidic residues
Compositional bias788-809Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABPRJ010000982
EMBL· GenBank· DDBJ
VVC34065.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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