A0A5E4MT37 · A0A5E4MT37_9HEMI
- ProteinProtein kibra
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1062 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cytoplasm | |
Molecular Function | kinase binding | |
Molecular Function | molecular adaptor activity | |
Biological Process | cell migration | |
Biological Process | negative regulation of organ growth | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of hippo signaling |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein kibra
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Lachninae > Cinara
Accessions
- Primary accessionA0A5E4MT37
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-42 | WW | ||||
Sequence: IPLPDGWDFARDYDGKVYFIDHNTKKTTWIDPRD | ||||||
Domain | 56-89 | WW | ||||
Sequence: NELPLGWEEAIDPVIGVYYINHFNQCTQLEDPRL | ||||||
Region | 262-287 | Disordered | ||||
Sequence: TDDPDLQNHSSSTQLSDKLSTASQTD | ||||||
Coiled coil | 302-336 | |||||
Sequence: MARMRLEYDEARKRIQNIQQQLADLEEKVMPGQEE | ||||||
Coiled coil | 361-430 | |||||
Sequence: RSRSHREMTDIQGEIKKLEQDLNNALEMSNRAITDRLRLHEEKQLLLQQLKEALRSMTLLESQLKTLSAS | ||||||
Region | 435-454 | Disordered | ||||
Sequence: SSSSSLGSLSTTSSKGSLSS | ||||||
Region | 495-538 | Disordered | ||||
Sequence: QPPAYETMGESSNTVSNVTGVPYSRSCRPTSPPLSPISETPPRS | ||||||
Compositional bias | 499-527 | Polar residues | ||||
Sequence: YETMGESSNTVSNVTGVPYSRSCRPTSPP | ||||||
Domain | 564-690 | C2 | ||||
Sequence: STETSQVQIRLRYSIAEQVLHVCIERLRNVVALSIAESWQLFVKISLLPSGSNSSLSGCTKPISDLAKPRFGDSFAFNLPSNKLCTKTLQVNVWGLGPEDITECLACAQVSLAEFNETENNSWCKWY | ||||||
Region | 752-776 | Disordered | ||||
Sequence: NGVEYEDGDSDDSVSDDDDEEEDDD | ||||||
Compositional bias | 753-776 | Acidic residues | ||||
Sequence: GVEYEDGDSDDSVSDDDDEEEDDD | ||||||
Compositional bias | 788-809 | Basic and acidic residues | ||||
Sequence: KELEQVLESPDKENDTEDKETN | ||||||
Region | 788-822 | Disordered | ||||
Sequence: KELEQVLESPDKENDTEDKETNTEGAFSGSNGENN |
Sequence similarities
Belongs to the WWC family. KIBRA subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,062
- Mass (Da)119,369
- Last updated2019-11-13 v1
- Checksum31278A9995A1B00F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5E4MRH6 | A0A5E4MRH6_9HEMI | CINCED_3A011339 | 990 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 499-527 | Polar residues | ||||
Sequence: YETMGESSNTVSNVTGVPYSRSCRPTSPP | ||||||
Compositional bias | 753-776 | Acidic residues | ||||
Sequence: GVEYEDGDSDDSVSDDDDEEEDDD | ||||||
Compositional bias | 788-809 | Basic and acidic residues | ||||
Sequence: KELEQVLESPDKENDTEDKETN |
Keywords
- Technical term