A0A4Z1EY44 · A0A4Z1EY44_9HELO

  • Protein
    ATP-dependent DNA helicase II subunit 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentKu70:Ku80 complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondamaged DNA binding
Molecular Functionhelicase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 2
  • EC number

Gene names

    • ORF names
      BTUL_0020g00600

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bt9001
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Botrytis

Accessions

  • Primary accession
    A0A4Z1EY44

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-215VWFA

Sequence similarities

Belongs to the ku80 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    80,671
  • Last updated
    2019-09-18 v1
  • Checksum
    86CC8FED6C20816D
MEKQATVYVVDLGKSLGDCHHGRVETDLEYGMRYVWDKITLTMSTDRKTEGIGIVGFRTDETDNELHSGGEEGYANISVLKHLGQFQMQQLEEVKEAVKPSNTDDGDAISAIVVAMEMIKKHTTLKSGKPGKYARKIVLITDGNGFMNGEELDDIAKEINNNDIRLVVIGVDFDDAEYGFKEEDKDLVKSENEKLLRSFTEKCSDGTFGTTAEAIEALATPVVKVTREYNTYTGPLTLGDVKKCPETAISIDVARYFKTKQAKPVSAKSYVDRVTDEPIDVDLADADHLTSVTQARTYKVNDPTAPGGKRDVEKDALERGYDYGSTIVPISQSDESVTKLQTTKDFSIMGFVPNDYERYLNMGESCITIAQKTNEKARMALSSLIRALHELESCAVARIVKKDGSDPLIVLLAPFIEPGLEGLIDVPLPFAEDVRTYRFAPLDKVFNSSGGIMEKHKNLPSNDLKAAMGKFVDSMDLSTAGKDDEGEPAEYMAIEDTYSPVLHRINQAIRRRAVKPDEGIPPPPDVLTKWSHPPTQLVEKSSSQLEKLIEASDVKKVPATAKAKRNREVVKPLSGLDVEALLGREKRQKITVENAIPEFKRALSSTDSTDSVVKVTREMGDTVRTLLKRSTGNSTWDQAGEYLRTMRTELIELIEPNIYNNFIEKFKKQLQNGDFDKSFWFDVVRKNKLGLIHGGEAENTEKTEDEARQFYHLNTGELPNRGKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PQXH01000020
EMBL· GenBank· DDBJ
TGO17174.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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