A0A4Z0ZXJ3 · A0A4Z0ZXJ3_9LEPT

  • Protein
    ATP-dependent 6-phosphofructokinase
  • Gene
    pfkA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site80ATP (UniProtKB | ChEBI)
Binding site146-147ATP (UniProtKB | ChEBI)
Binding site171-174ATP (UniProtKB | ChEBI)
Binding site172Mg2+ (UniProtKB | ChEBI); catalytic
Site173Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site200-202substrate
Active site202Proton acceptor
Binding site245-247substrate
Binding site301substrate
Binding site353-356substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      pfkA
    • ORF names
      EHQ62_14955

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 201702451
  • Taxonomic lineage
    Bacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira

Accessions

  • Primary accession
    A0A4Z0ZXJ3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain73-378Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    47,546
  • Last updated
    2019-09-18 v1
  • Checksum
    981AE889789F8E3D
MNQNDTKVEQFGPCTIPNPAGYDYWTEDNSVVLFQTIFSGPDDAKKTIDSSPVFFEQAGPKEKIYYRPEEVTAGIVTCGGLCPGINDVIRALVMELHYRYKVPRILGFPFGYEGLVKKFGHRPVELTPDKVAHIMNFGGSILGSSRGNQKIEDMVDTLFLYGVKMLFCIGGDGTLRGAEAIQAEIKKRKEDIAIVGIPKTIDNDINYVQKTFGFSTAFSKAVEAVNCAHEEAKGAPNGIGLVKLMGRHSGFIAVNSALASKNVNFVLIPELDFDLEGEGAFLPVLLDRVKRRGHAVVIVAEGAGQKYFEDKGEKDRSGNKKLADIGVFMKDKITEYFQKEGAALNLKYIDPSYIIRSVPANAEDSVFCGFLAQNAVHAAFAGRTGCVVGIWNNVFTVMPISLAIAERKVLRPERSTLWRALLASTGQPNSMKAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RQGH01000028
EMBL· GenBank· DDBJ
TGL62610.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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