A0A4W2ILY6 · A0A4W2ILY6_BOBOX
- ProteinRUNX family transcription factor 2
- GeneRUNX2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids515 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | chondrocyte differentiation | |
Biological Process | hemopoiesis | |
Biological Process | neuron differentiation | |
Biological Process | ossification | |
Biological Process | regulation of cell differentiation |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Laurasiatheria > Artiodactyla (even-toed ungulates & whales) > Ruminantia > Pecora > Bovidae > Bovinae > Bos (oxen, cattle)
Accessions
- Primary accessionA0A4W2ILY6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-52 | Disordered | ||||
Sequence: MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQ | ||||||
Compositional bias | 10-52 | Polar residues | ||||
Sequence: SRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQ | ||||||
Domain | 84-212 | Runt | ||||
Sequence: TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRR | ||||||
Compositional bias | 204-225 | Basic and acidic residues | ||||
Sequence: VDGPREPRRHRQKLDDSKPSLF | ||||||
Region | 204-392 | Disordered | ||||
Sequence: VDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTPPSIHSTTPLSSTRGTGLPAITDVPRRISDSEPSTLDSQSSTTLFLSSEEPGPSTAALPSPSSSCEPSAFSPGPPALPHLLPSLPTAPAPAASGSGAP | ||||||
Compositional bias | 242-256 | Pro residues | ||||
Sequence: VGVPPQNPRPSLNSA | ||||||
Compositional bias | 257-312 | Polar residues | ||||
Sequence: PSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTPPSIHSTTPLSSTRGTGL | ||||||
Compositional bias | 322-363 | Polar residues | ||||
Sequence: ISDSEPSTLDSQSSTTLFLSSEEPGPSTAALPSPSSSCEPSA | ||||||
Compositional bias | 365-379 | Pro residues | ||||
Sequence: SPGPPALPHLLPSLP | ||||||
Region | 412-465 | Disordered | ||||
Sequence: LDWLPGGPSATPPSTRGDERDRPGPRAPRPGTVGREEGAEDLGASPQPCARPAT |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length515
- Mass (Da)54,556
- Last updated2019-09-18 v1
- Checksum00FB55478F4EF72C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 10-52 | Polar residues | ||||
Sequence: SRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQ | ||||||
Compositional bias | 204-225 | Basic and acidic residues | ||||
Sequence: VDGPREPRRHRQKLDDSKPSLF | ||||||
Compositional bias | 242-256 | Pro residues | ||||
Sequence: VGVPPQNPRPSLNSA | ||||||
Compositional bias | 257-312 | Polar residues | ||||
Sequence: PSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTPPSIHSTTPLSSTRGTGL | ||||||
Compositional bias | 322-363 | Polar residues | ||||
Sequence: ISDSEPSTLDSQSSTTLFLSSEEPGPSTAALPSPSSSCEPSA | ||||||
Compositional bias | 365-379 | Pro residues | ||||
Sequence: SPGPPALPHLLPSLP |