A0A4R5WAM9 · A0A4R5WAM9_MYCMU
- ProteinAnthranilate synthase component 1
- GenetrpE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids501 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Catalytic activity
- chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H+
Cofactor
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | anthranilate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnthranilate synthase component 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A4R5WAM9
Proteomes
Interaction
Subunit
Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-169 | Anthranilate synthase component I N-terminal | ||||
Sequence: DSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPSALTVRDGEAVWLGNTPQDAPSGGDPLQAVRDTLALLQTAPVPGLPPLSSGLVGYFAYDMVRRLERLPELAVDDLKLPDMVLLLATDMAAVDHHEGTITL | ||||||
Domain | 226-484 | Chorismate-utilising enzyme C-terminal | ||||
Sequence: EEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTAADPIDVYRVLRVTNPSPYMYLLNVPNAEGGLDFSVVGSSPEALVTVKDGVATTHPIAGTRWRGATEEDDILLEKELLADDKERSEHLMLVDLGRNDLGRVCKPGTVRVEDYSHIERYSHVMHLVSTVTGHLADDKTALDAVTACFPAGTLSGAPKVRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALMRAGTAYVQAGGGVVADSNGPYEYNESSNK |
Sequence similarities
Belongs to the anthranilate synthase component I family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length501
- Mass (Da)54,067
- Last updated2019-07-31 v1
- ChecksumBCF0170310BADC4E