A0A4R5P6S6 · A0A4R5P6S6_9MYCO

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site100-102substrate
Binding site124-127substrate; in site B
Binding site134-136substrate
Binding site182substrate
Active site183Proton donor/acceptor
Active site314
Binding site315substrate
Binding site320-322substrate
Site327Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      EJ571_21570

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 45524
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacteroides

Accessions

  • Primary accession
    A0A4R5P6S6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-338Fumarate lyase N-terminal
Domain404-460Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    49,068
  • Last updated
    2019-07-31 v1
  • Checksum
    92A929A693F8A2B8
MSEQQYRIEHDTMGEVRVPVEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAPEKADAIIAAAQEIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAANNGVTVHPNDDVNMSQSSNDTFPTATHLAATEAAARDLIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGVERVKATLPRLGELPIGGTAVGTGLNAPDGFGAKVVEVLKQSTGLSELKTATDSFEAQAARDGLVEASGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLIANEEHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALKQRKTIRQTVIDRGLIGDKLSVEELDKRLDVLAMAKVKD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RXLR01000019
EMBL· GenBank· DDBJ
TDH19162.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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