A0A4Q7G3I6 · A0A4Q7G3I6_9BRAD

Function

function

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionadenylate cyclase activity
Molecular Functionmetal ion binding
Molecular Functiontransferase activity
Biological Processcyclic nucleotide biosynthetic process
Biological Processintracellular signal transduction
Biological Processthiamine biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine pyrimidine synthase

Gene names

    • ORF names
      CWO90_18825

Organism names

  • Taxonomic identifier
  • Strain
    • Leo121
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Bradyrhizobium

Accessions

  • Primary accession
    A0A4Q7G3I6

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane342-359Helical
Transmembrane371-396Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain813-945Guanylate cyclase

Sequence similarities

Belongs to the NMT1/THI5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,060
  • Mass (Da)
    116,808
  • Last updated
    2019-07-31 v1
  • Checksum
    58FC79FCFD0EFFE7
MSAGLDMSAAQMLRHGRDVLFALCLVVELVFGRVTPAHALEQVSLQLKWKHQFQFAGYYAAVEKGFYRDNGLDVSVREGGPGIDAGLEVAKGAADFGVCTTSVFVNSAERANNVVLAVIFQHSAAIILVLHRAGIHAVSELKGHALMDAPGSDDIAAMLKHEGVGYADLPRIAHSGNPRDLLSGKADAMVAYSTNEPYLFEEYGTPYLAFSPRAYGFDFYGDNLCTSKRQIAAHPERVAAFREASLRGWAYALAHKEEIADLIRGKYAAQKTQKALLFEAARTELLIEPHLTPIGQQSVARWNAIARAYVDLGMLDEAKLPEGLIYASDDQSWRSQMRDPRPWAFLAVVAAILLSRILYRRIAPAIGALRLSAAMSGLFVLLSIPALIFILAYNYWQNSATINATLNDVVAKTKRASIDDARGLINPVEATLELLASFAAEDPEIFKKEESRELLHEALTSAPQIDAVYVSLEDGYHRVVTRIDDDRRRSDPKIPATANWHSGYIDSFSGSPRRVRHRTFYDTWPHVVGSYDVGTIEDIRTLAGYQAAKDARALIIEGPRPNPDTGFPVIIVRVPIIKDGAFVGCASANITLNVLSQFLTSHRASPRSTTVIANPTDGTIISYPDPKKGVRLENDRLEMARLDTIDDPNVREAHRLQSDTNRDDFLFRSPQGGEEISASFARFPGSFGKPWEVITLTPTDDFIRTLKRTNRQMVALIAALTGIELLLIHFFSRRLSRPIECVSQDLRSVEDLTFSHGVATPSKIKEIKELQTAVKLFETSLRSFSSFVPLGIVRNLIKTGTPLTLGVEQRFMTVLFTDLKDFSTLSEQMAPNDLLAQLSHYFEVVSHAIAEESGTVDKFIGDGIMAFWGAPVHRDDDVLRGCCGAMRATRRMEQLNADWSKQGRPSLHLRIGLHCAEVLVGNVGSSERLSYTVMGDGVNVAARLEGINKNFGTTICISDSVVEAVGPEIVARPIRKVQVKGRKREFMIYELLGIKASDDPELQASDNAARLCDLTWEASLHFERGEFDQAARRYEGILTAFPDDSVAKSLLAMCSAKASA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PSRS01000055
EMBL· GenBank· DDBJ
RZN30876.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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