A0A4M5PYF9 · A0A4M5PYF9_STREE

  • Protein
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit
  • Gene
    tagE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in the substrate protein. Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

Features

Showing features for binding site.

150350100150200250300350400450500
TypeIDPosition(s)Description
Binding site16-19UDP (UniProtKB | ChEBI)
Binding site242N-acetyl-D-glucosamine (UniProtKB | ChEBI)
Binding site384-385UDP (UniProtKB | ChEBI)
Binding site404-407N-acetyl-D-glucosamine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentprotein N-acetylglucosaminyltransferase complex
Molecular Functionglycosyltransferase activity
Molecular Functionnucleotide binding
Biological Processprotein O-linked glycosylation via serine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit
  • EC number
  • Alternative names
    • Glycosyltransferase GtfA

Gene names

    • Name
      tagE
    • Synonyms
      gtfA
    • ORF names
      SAMEA4038883_01881

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GPSC559
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    A0A4M5PYF9

Proteomes

Subcellular Location

Cytoplasm
Cell membrane
; Peripheral membrane protein
Note: Cell membrane association requires GtfB.

Keywords

Interaction

Subunit

Forms a heterotetramer with 2 subunits each of GtfA and GtfB. Part of the accessory SecA2/SecY2 protein translocation apparatus.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain95-191GtfA extended beta-sheet meander

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    57,767
  • Last updated
    2019-09-18 v1
  • Checksum
    821F3A4F37DA3164
MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMILADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVTVDDVLAYFGGEESHREKNGKVLRVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSYTRYCSEYFAPKDNVAVLYQRTFYNEDGTPVYDILMNQGKEEVYHFKDKIFYGKQAFVRAFMKSLNLNKSDLVILDRETGIGQVVFEEAQTAHLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFIVSTDRQNEVLQEQFAKYTQHQPKIVTIPVGSIDSLTDSSQGRKPFSLITASRLAKEKHIDWLVKAVIEAHKELPELTFDIYGSGGEDSLLRDIIANHQAENYIQLKGHAELSQIYSQYEVYLTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVEDQIKQAYAAKICQLYQENRLEAMRAYSYQIAEGFLTKEILEKWKKTVEEVLHD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABDLL010000015
EMBL· GenBank· DDBJ
VTE41356.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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