A0A498H2F0 · A0A498H2F0_9EURY

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34-36ATP (UniProtKB | ChEBI)
Binding site86-87ATP (UniProtKB | ChEBI)
Binding site119Mg2+ 1 (UniProtKB | ChEBI)
Binding site158Mg2+ 2 (UniProtKB | ChEBI)
Active site181
Binding site183D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site207D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site211-215D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processnucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      ABH15_02010

Organism names

  • Taxonomic identifier
  • Strain
    • CYW4
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanomicrobiales > Methanomicrobiaceae > Methanoculleus

Accessions

  • Primary accession
    A0A498H2F0

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-107Ribose-phosphate pyrophosphokinase N-terminal
Domain125-239Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    282
  • Mass (Da)
    29,713
  • Last updated
    2019-06-05 v1
  • Checksum
    14A98B163E9EEC0A
MKIISTERSQVLAARVSEITGYQLLDTKFNRFPDGELYLRTGETDEETIIVSSVVDNDALVQTLLAIDACDSSRITLVLPYLGYARQDKRFTAGEPISARAVARALSRGVDQICVVNIHDPAVLQYFDAPATNISIAPAIGGYIRELGVRNPLILAPDDGAAAFAAEVAAVGGWDTDHLEKTRLSGDTVRMEPKSLPAASREVVIVDDIISTGGTLATAAGMLYGQGATAIHAVCVHGVLSSGAYARLRAAGVASVASSDTYENATSCISAASAIAERLRQC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LHQS01000001
EMBL· GenBank· DDBJ
RXE56943.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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