A0A3W0KM61 · A0A3W0KM61_SALET

  • Protein
    Anthranilate synthase component 1
  • Gene
    trpE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40L-tryptophan (UniProtKB | ChEBI)
Binding site291-293L-tryptophan (UniProtKB | ChEBI)
Binding site328-329chorismate (UniProtKB | ChEBI)
Binding site361Mg2+ (UniProtKB | ChEBI)
Binding site449chorismate (UniProtKB | ChEBI)
Binding site469chorismate (UniProtKB | ChEBI)
Binding site483-485chorismate (UniProtKB | ChEBI)
Binding site498Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionanthranilate synthase activity
Molecular Functionmetal ion binding
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate synthase component 1
  • EC number

Gene names

    • Name
      trpE
    • ORF names
      AXN14_04845
      , G0H73_23545

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 14ARS_STU0125
    • CFSAN031443
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A3W0KM61

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-191Anthranilate synthase component I N-terminal
Domain243-502Chorismate-utilising enzyme C-terminal

Sequence similarities

Belongs to the anthranilate synthase component I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    57,152
  • Last updated
    2019-05-08 v1
  • Checksum
    C43B65A620E8D100
MQTPKPTLELLTCDAAYRENPTALFHQVCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALCDTVTIQALSDNGASLLPLLDTALPAGVENEVLPAGRILRFPPVSPLLDEDARLCSLSVFDAFRLLQGVVNIPTQEREAMFFGGLFAYDLVAGFEALPHLEAGNNCPDYCFYLAETLMVIDHQKKSTRIQASLFTASDREKQRLNARLAYLSQQLTQPAPSLPVTPVPDMRCECNQSDDAFGAVVRQLQKAIRAGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDAASRQIEIYPIAGTRPRGRRADGTLDRDLDSRIELDMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIADAEGQRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATVQAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGNPF010000002
EMBL· GenBank· DDBJ
EBQ0115230.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMVH010000024
EMBL· GenBank· DDBJ
HAC8335717.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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