A0A3S5AAV3 · A0A3S5AAV3_9NEIS

  • Protein
    NADH-quinone oxidoreductase subunit I
  • Gene
    nuoI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

115920406080100120140
TypeIDPosition(s)Description
Binding site60[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site63[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site66[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site70[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site99[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site102[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site105[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site109[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit I
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit I
    • NDH-1 subunit I

Gene names

    • Name
      nuoI
    • ORF names
      NCTC12742_01232

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC12742
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A3S5AAV3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-804Fe-4S ferredoxin-type
Domain90-1194Fe-4S ferredoxin-type

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    18,351
  • Last updated
    2019-04-10 v1
  • Checksum
    065424CD9F9A6DF7
MANFVKIFLLGELVKGMGLTLKNFFARKETIYFPEEKTPQSVRFRGLHAQRRYPNGEERCIACKLCEAVCPAMAINIESEEREDGTRRTTRYDIDLTKCIFCGFCEEACPVDAIVETHIFEYHGEKRGDLHYTKPMLLAIGDRYEDEIAKRKAADAPYR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134533
EMBL· GenBank· DDBJ
VEJ51351.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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