A0A3Q0QNH1 · A0A3Q0QNH1_AMPCI

Function

function

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Features

Showing features for binding site.

128320406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site66phosphate (UniProtKB | ChEBI)
Binding site110-113phosphate (UniProtKB | ChEBI)
Binding site189substrate
Binding site191substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionuridine phosphorylase activity
Biological Processnucleoside catabolic process
Biological Processnucleotide catabolic process
Biological ProcessUMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridine phosphorylase
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > New World cichlids > Cichlasomatinae > Heroini > Amphilophus

Accessions

  • Primary accession
    A0A3Q0QNH1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond61↔68Redox-active

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-275Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    31,532
  • Last updated
    2019-04-10 v1
  • Checksum
    33306985DB2D9BE7
MEEDILYHFSLSTKTHNLPEMFGDIKFVCVGGSANRMKAFAQFIHQELKLPGNPEDIKDICEGTDRYCMYKVGPVLSISHGMGVPSISIMLHELIKLLHHAHCRDVVLFRLGTSGGVGLAPGTVVVTDKAVDYSFRPQFEQVVLGKVITRSTELDEGVANELLQCSSELQTFPTVIGNTMCTHDFYEGQGRLDGALCSFSQEEKLEYLRKAYEAGVRNIEMESTVFAAMCRVCGLKGAVVCVTLLNRFEGDQITSPHDVLVDYQHRPQILVAHFIKKRLGYIV

Genome annotation databases

Similar Proteins

Disclaimer

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