A0A3M2SBR5 · A0A3M2SBR5_9HYPO

  • Protein
    NADPH-dependent diflavin oxidoreductase 1
  • Gene
    TAH18
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H2O2-induced cell death.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site14-19FMN (UniProtKB | ChEBI)
Binding site61-64FMN (UniProtKB | ChEBI)
Binding site99-108FMN (UniProtKB | ChEBI)
Binding site134FMN (UniProtKB | ChEBI)
Binding site358FAD (UniProtKB | ChEBI)
Binding site388-391FAD (UniProtKB | ChEBI)
Binding site429-432FAD (UniProtKB | ChEBI)
Binding site472NADP+ (UniProtKB | ChEBI)
Binding site528-529NADP+ (UniProtKB | ChEBI)
Binding site534-538NADP+ (UniProtKB | ChEBI)
Binding site598FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processiron-sulfur cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent diflavin oxidoreductase 1
  • EC number
  • Alternative names
    • NADPH-dependent FMN and FAD-containing oxidoreductase

Gene names

    • Name
      TAH18
    • ORF names
      CDV36_005366

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UCR3666
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium solani species complex

Accessions

  • Primary accession
    A0A3M2SBR5

Proteomes

Subcellular Location

Cytoplasm
Mitochondrion
Note: Relocalizes to mitochondria after H2O2 exposure.

Keywords

Interaction

Subunit

Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-152Flavodoxin-like
Domain210-465FAD-binding FR-type

Sequence similarities

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    68,516
  • Last updated
    2019-02-13 v1
  • Checksum
    09010F4B17C23C75
MAVQDRTVLILYGSETGNAQDMAEELGRVCQRLHFKSRVEELDAVDLNALLQHRFVIFVISTTGQGDMPHNSLLFWKRLLRKKLPPGCLSSVQYTTFGLGDSTYLKFNWAARKLNRRLEQLGATTFIESFEADEQFPDGIDGSFVRWSETLSKHLLEHHPPPFGLKPIPDNVILPPKWSLKSALENSQVVNGHSSPQLSELPPASLLPIPNGWTATLADNVRFTPETHWQDVRLVSFDIPKRDGVKLQCNPGDCLTIYPKNFPQDAQKLITLMGWDDIADKPLDLSLCDSLPQNLYIDPKCTLREIILNNIDFTAIPRRSFLKSMSYFSTNPGHKERLLEFTMTEYLDEYFDYATRSRRSILEVLEEFTSVKLPAERVLDIFPLIRGRDFSIANGGMKLKHPTNEDITRVELLVALVKYRTILRKPRQGLCSRYLENLPAGSSLTVTHKPVLSPIHGPQNAQRPLVAIATGTGLAPIRALIHERLTHPLRAPIHLFFGNRNRDADYFFHDEWDAAVRDGNLDVFLAFSRDQRTKIYVQDRLREEAKRLEGPILDNGIFCVCGGSTKMADAAKRAVFEPFSEGAEDAEGRKKVLSTLTWWQEIW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NKUJ01000073
EMBL· GenBank· DDBJ
RMJ14986.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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